ZFYVE19

Gene Symbol ZFYVE19
Entrez Gene 84936
Alt Symbol ANCHR, MPFYVE
Species Human
Gene Type protein-coding
Description zinc finger, FYVE domain containing 19
Other Description MLL partner containing FYVE domain|abscission/NoCut checkpoint regulator|zinc finger FYVE domain-containing protein 19
Swissprots Q8WU96 Q86WC2 H3BUF9 Q96K21 B3KVB2 C9JNF4
Accessions EAW92447 EAW92448 EAW92449 EAW92450 EAW92451 EAW92452 EAW92453 EAW92454 EAW92455 Q96K21 AB209224 BAD92461 AF445414 AAO73862 AK027746 BAB55338 AK122779 BAG53724 AK225553 BC015738 BC021092 AAH21092 BI860679 DA611931 DA653225 DB012963 DQ575146 XR_931925 NM_001077268 NP_001070736 NM_001258420 NP_001245349 NM_001258421 NP_001245350 NM_032850 NP_116239
Function Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. {ECO:0000269|PubMed:24814515}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24814515}. Cleavage furrow {ECO:0000269|PubMed:24814515}. Midbody {ECO:0000269|PubMed:24814515}. Note=Localizes mainly on centrosomes in interphase and early mitosis. Localizes at the cleavage furrow and midbody ring in late mitosis and cytokinesis (PubMed:24814515). {ECO:0000269|PubMed:24814515}.
Tissue Specificity Detected in brain, heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:12618766}.

ZFYVE19-Over-expression-Lysate - LY16210a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag ZFYVE19 (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ZFYVE19 gene‘

ZFYVE19 293T Cell Transient Overexpression Lysate(Denatured) - H00084936-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

ZFYVE19 overexpression lysate - LY421396 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

ZFYVE19 Overexpression Lysate (Denatured) - H00084936-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: ZFYVE19 transfected lysate (36.19 KDa) Lane 2: Non-transfected lysate.

ZFYVE19 Overexpression Lysate (Native) - NBP2-08452 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: ZFYVE19 Overexpression Lysate (Adult Normal) [NBP2-08452] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZFYVE19.

ZFYVE19 Overexpression Lysate (Denatured) - H00084936-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human ZFYVE19 Knockdown Stable Cell Line - CSC-DC017814 from Creative biogene

Category Cell Line
Species Human
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