PDGFB

Gene Symbol	PDGFB
Entrez Gene	5155
Alt Symbol	IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis
Species	Human
Gene Type	protein-coding
Description	platelet-derived growth factor beta polypeptide
Other Description	PDGF subunit B|PDGF, B chain|becaplermin|platelet-derived growth factor 2|platelet-derived growth factor B chain|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|platelet-derived growth factor subunit B|platelet-derived growth factor, beta polypeptide (oncogene SIS)|proto-oncogene c-Sis
Swissprots	P01127 P78431 Q15354 Q9UF23 Q6FHE7 G3XAG8
Accessions	AAA60349 AAA60552 AAA98793 CAA02289 CAA02294 CAA25226 CAA25227 CAA25228 CAA25229 CAA25230 CAA67262 CAE82038 CAH23424 CAI06107 CAJ32895 CAJ32907 CAL32766 CBH30542 EAW60305 EAW60306 EAW60307 EAW60308 P01127 AK022920 BC029822 AAH29822 BC077725 AAH77725 BM983641 CR456538 CAG30424 CR541807 CAG46606 CU013138 CAK54569 CU013426 CAK54868 M12783 AAA60553 M32009 X02744 CAA26524 X02811 CAA26579 X03702 CAA27333 X83705 CAA58679 NM_002608 NP_002599 NM_033016 NP_148937
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.
Subcellular Location	Secreted. Note=Released by platelets upon wounding.
Tissue Specificity	Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. {ECO:0000269|PubMed:11331882}.
Top Pathways	Rap1 signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDGFB-Over-expression-Lysate - LY13016a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PDGFB 293T Cell Transient Overexpression Lysate(Denatured) - H00005155-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PDGFB overexpression lysate - LY400920 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PDGFB overexpression lysate - LY409779 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PDGFB overexpression lysate - LY429841 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PDGF-B Overexpression Lysate (Denatured) - H00005155-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PDGF-B (h): 293T Lysate - sc-114500 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Cynomolgus PDGFB / PDGF-BB HEK293 Cell Lysate (WB positive control) - 90030-C04HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

PDGF-B Overexpression Lysate (Native) - NBP2-04230 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human PDGFB Knockdown Stable Cell Line - CSC-DC011522 from Creative biogene Category Cell Line Species Human

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