PDGFB

Gene Symbol	PDGFB
Entrez Gene	5155
Alt Symbol	IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis
Species	Human
Gene Type	protein-coding
Description	platelet-derived growth factor beta polypeptide
Other Description	PDGF subunit B|PDGF, B chain|becaplermin|platelet-derived growth factor 2|platelet-derived growth factor B chain|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|platelet-derived growth factor subunit B|platelet-derived growth factor, beta polypeptide (oncogene SIS)|proto-oncogene c-Sis
Swissprots	P01127 P78431 Q15354 Q9UF23 Q6FHE7 G3XAG8
Accessions	AAA60349 AAA60552 AAA98793 CAA02289 CAA02294 CAA25226 CAA25227 CAA25228 CAA25229 CAA25230 CAA67262 CAE82038 CAH23424 CAI06107 CAJ32895 CAJ32907 CAL32766 CBH30542 EAW60305 EAW60306 EAW60307 EAW60308 P01127 AK022920 BC029822 AAH29822 BC077725 AAH77725 BM983641 CR456538 CAG30424 CR541807 CAG46606 CU013138 CAK54569 CU013426 CAK54868 M12783 AAA60553 M32009 X02744 CAA26524 X02811 CAA26579 X03702 CAA27333 X83705 CAA58679 NM_002608 NP_002599 NM_033016 NP_148937
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.
Subcellular Location	Secreted. Note=Released by platelets upon wounding.
Tissue Specificity	Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. {ECO:0000269|PubMed:11331882}.
Top Pathways	Rap1 signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDGF AB full length protein - ab52112 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Human

Active human PDGF AB full length protein - ab179496 from Abcam Category Protein Prices $202.00 Sizes 10 µg Source E. coli Species Human

Active human PDGF AB full length protein - ab73228 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Human

Active human PDGF BB full length protein - ab155718 from Abcam Category Protein Prices $239.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human PDGF BB full length protein - ab79746 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Human

Active human PDGF BB full length protein - ab179626 from Abcam Category Protein Prices $202.00 Sizes 10 µg Source E. coli Species Human

Active human PDGF BB full length protein - ab191740 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human PDGFAA + PDGFBB full length protein - ab61903 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source E. coli Species Human

Active mouse PDGF BB full length protein - ab78593 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse PDGF BB full length protein - ab51925 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Mouse

Active mouse PDGF BB full length protein - ab73233 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Mouse

Active PDGF BB full length protein - ab9706 from Abcam Category Protein Prices $110.00, $257.00 Sizes 2 µg, 10 µg Source E. coli

Human PDGF BB full length protein - ab73231 from Abcam Category Protein Source E. coli Species Human

Human PDGF BB peptide - ab24035 from Abcam Category Peptide

PDGF-BB Antibody Blocking Peptide - LS-E4839 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGF-BB Antibody Blocking Peptide - LS-E31391 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PDGF-BB Antibody Blocking Peptide - LS-E21407 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PDGF-BB Protein - NBP2-35203 from Novus Biologicals Category Protein Prices $69.00, $169.00, $669.00, $3,469.00 Sizes 2 µg, 10 µg, 100 µg, 1 mg Source E. coli Species Human

Recombinant Rat PDGF-BB Protein - NBP2-35285 from Novus Biologicals Category Protein Prices $69.00, $175.00, $3,469.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Rat

PDGF-B Protein - NBP1-43180 from Novus Biologicals Category Protein Prices $229.00 Sizes 5 µg Species Human

PDGF-B Partial Recombinant Protein - H00005155-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDGF-B Recombinant Protein - P3661 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDGF-B Recombinant Protein - P4572 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

PDGF-B Protein - NBP1-99851 from Novus Biologicals Category Protein Prices $309.00 Sizes 10 µg Species Human

PDGF-B Protein - NBP1-99951 from Novus Biologicals Category Protein Species Human

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