PDGFB

Gene Symbol PDGFB
Entrez Gene 5155
Alt Symbol IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis
Species Human
Gene Type protein-coding
Description platelet-derived growth factor beta polypeptide
Other Description PDGF subunit B|PDGF, B chain|becaplermin|platelet-derived growth factor 2|platelet-derived growth factor B chain|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|platelet-derived growth factor subunit B|platelet-derived growth factor, beta polypeptide (oncogene SIS)|proto-oncogene c-Sis
Swissprots P01127 P78431 Q15354 Q9UF23 Q6FHE7 G3XAG8
Accessions AAA60349 AAA60552 AAA98793 CAA02289 CAA02294 CAA25226 CAA25227 CAA25228 CAA25229 CAA25230 CAA67262 CAE82038 CAH23424 CAI06107 CAJ32895 CAJ32907 CAL32766 CBH30542 EAW60305 EAW60306 EAW60307 EAW60308 P01127 AK022920 BC029822 AAH29822 BC077725 AAH77725 BM983641 CR456538 CAG30424 CR541807 CAG46606 CU013138 CAK54569 CU013426 CAK54868 M12783 AAA60553 M32009 X02744 CAA26524 X02811 CAA26579 X03702 CAA27333 X83705 CAA58679 NM_002608 NP_002599 NM_033016 NP_148937
Function Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}.
Subcellular Location Secreted. Note=Released by platelets upon wounding.
Tissue Specificity Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. {ECO:0000269|PubMed:11331882}.
Top Pathways Rap1 signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction

PDGF-B (F-3) - sc-365805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDGF-B (F-3): sc-365805. Western blot analysis of PDGF-B expression in HeLa whole cell lysate.

PDGF-B (C-5) - sc-74494 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDGF-B (C-5): sc-74494. Western blot analysis of human recombinant PDGF-B.

PDGF-B (H-55) - sc-7878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDGF-B (H-55): sc-7878. Western blot analysis of human recombinant PDGF-B.

PDGF-B (N-30) - sc-127 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDGF-B (N-30): sc-127. Western blot analysis of 10 ng of human recombinant PDGF-B showing detection of dimeric form.

PDGF-B (MM0014-5F66) - sc-101568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-PDGF BB antibody - ab23914 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab23914 staining PDGF BB (green) in mouse skeletal muscle tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 10% serum for 10 minutes at 25°C; antigen retrieval was by heat mediation in Tris pH 9. Samples were incubated with primary antibody (1/500 in antibody diluent reagent) for 14 hours at 4°C. An Alexa Fluor® 647-conjugated goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody. DAPI (blue) - nuclei.See Abreview

Anti-PDGF BB antibody - ab21234 from Abcam

Prices $382.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Formalin fixed paraffin embedded human angiosarcoma stained with PDGF B using ABC and AEC chromogen.

Anti-PDGF BB antibody - ab9704 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab9704 staining PDGF BB in normal human skin tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent proteinase K mediated antigen retrieval. The primary antibody was used at 1 ug/ml and incubated with sample at 4°C overnight. A HRP-labeled polymer detection system was used with a non-alcohol soluble AEC chromogen.

Anti-PDGF BB antibody - ab139753 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
All lanes : Anti-PDGF BB antibody (ab139753) at 1 µg/mlLane 1 : Human PDGF BB full length protein (ab73231)Lane 2 : Active PDGF BB full length protein (ab9706)Lysates/proteins at 0.01 µg per lane.SecondaryGoat Anti-Chicken IgY H&L (HRP) (ab6877) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.Exposure time : 8 minutes

Anti-PDGF BB antibody - ab53716 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDGF BB antibody (ab53716) at 1/500 dilutionLane 1 : Extracts from NIH/3T3 cellsLane 2 : Extracts from NIH/3T3 cells, plus immunizing peptide

Anti-PDGF BB antibody - ab114130 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PDGF BB antibody (ab114130) at 1 µg/ml + Kidney (Human) Tissue Lysate - fetal normal tissue (ab30204) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PDGF BB antibody - ab10845 from Abcam

Prices $372.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-PDGF BB antibody - ab16829 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab16829 staining PDGF BB (green) in mouse adipose tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 10% serum for 10 minutes at 25°C; antigen retrieval was enzymatic in Tris (pH 10). Samples were incubated with primary antibody (1/100 in anitbody diluent reagent) for 14 hours at 4°C. An Alexa Fluor® 647-conjugated goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody. Dlue - DAPI, Red - Elastin.See Abreview

Anti-PDGF BB antibody (Biotin) - ab84265 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF BB antibody [MM0014-5F66] - ab51869 from Abcam

Prices $381.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0014-5F66
ab51869 at 1/200 dilution, staining PDGF BB in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-PDGF BB antibody - Carboxyterminal end - ab38561 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PDGF BB antibody - Carboxyterminal end (ab38561) at 1/100 dilution + A375 cell lysate

Anti-PDGF beta antibody - ab181341 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of human liver tissue labeling PDGF beta with ab181341 at 20 µg/ml

Anti-PDGF beta antibody - ab167131 from Abcam

Host Sheep
Clonality Polyclonal

Anti-PDGF beta antibody [EPR6834] - ab178409 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6834
All lanes : Anti-PDGF beta antibody [EPR6834] (ab178409) at 1/1000 dilutionLane 1 : Fetal brain lysateLane 2 : A375 lysateLane 3 : HeLa lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-PDGFAA + PDGFBB antibody - ab50201 from Abcam

Prices $370.00
Sizes 250 µg
Host Goat
Clonality Polyclonal

Anti-PDGF-BB Antibody (aa227-241) - LS-C3350 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-BB Antibody - LS-C38273 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PDGF-BB Antibody - LS-C42999 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDGF-BB Antibody - LS-C91968 from LifeSpan Bioscience

Prices $575.00
Sizes 1 ml
Host Sheep
Clonality Polyclonal

Anti-PDGF-BB Antibody - LS-C91967 from LifeSpan Bioscience

Prices $405.00
Sizes 1 mg
Host Rabbit
Clonality Polyclonal
Search more