PDGFB
| Gene Symbol | PDGFB |
|---|---|
| Entrez Gene | 5155 |
| Alt Symbol | IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis |
| Species | Human |
| Gene Type | protein-coding |
| Description | platelet-derived growth factor beta polypeptide |
| Other Description | PDGF subunit B|PDGF, B chain|becaplermin|platelet-derived growth factor 2|platelet-derived growth factor B chain|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|platelet-derived growth factor subunit B|platelet-derived growth factor, beta polypeptide (oncogene SIS)|proto-oncogene c-Sis |
| Swissprots | P01127 P78431 Q15354 Q9UF23 Q6FHE7 G3XAG8 |
| Accessions | AAA60349 AAA60552 AAA98793 CAA02289 CAA02294 CAA25226 CAA25227 CAA25228 CAA25229 CAA25230 CAA67262 CAE82038 CAH23424 CAI06107 CAJ32895 CAJ32907 CAL32766 CBH30542 EAW60305 EAW60306 EAW60307 EAW60308 P01127 AK022920 BC029822 AAH29822 BC077725 AAH77725 BM983641 CR456538 CAG30424 CR541807 CAG46606 CU013138 CAK54569 CU013426 CAK54868 M12783 AAA60553 M32009 X02744 CAA26524 X02811 CAA26579 X03702 CAA27333 X83705 CAA58679 NM_002608 NP_002599 NM_033016 NP_148937 |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. Note=Released by platelets upon wounding. |
| Tissue Specificity | Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung. {ECO:0000269|PubMed:11331882}. |
| Top Pathways | Rap1 signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction |
PDGF-B CRISPR/Cas9 KO Plasmid (h) - sc-400586 from Santa Cruz Biotechnology
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PDGF-B HDR Plasmid (h) - sc-400586-HDR from Santa Cruz Biotechnology
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PDGF-B Double Nickase Plasmid (h) - sc-400586-NIC from Santa Cruz Biotechnology
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PDGF-B Double Nickase Plasmid (h2) - sc-400586-NIC-2 from Santa Cruz Biotechnology
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PDGF-B CRISPR Activation Plasmid (h) - sc-400586-ACT from Santa Cruz Biotechnology
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PDGF-B CRISPR Activation Plasmid (h2) - sc-400586-ACT-2 from Santa Cruz Biotechnology
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PDGF-B Lentiviral Activation Particles (h) - sc-400586-LAC from Santa Cruz Biotechnology
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PDGF-B Lentiviral Activation Particles (h2) - sc-400586-LAC-2 from Santa Cruz Biotechnology
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PDGF-B siRNA (h) - sc-39705 from Santa Cruz Biotechnology
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PDGF-B shRNA Plasmid (h) - sc-39705-SH from Santa Cruz Biotechnology
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PDGF-B shRNA (h) Lentiviral Particles - sc-39705-V from Santa Cruz Biotechnology
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PDGF-B RNAi - H00005155-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN16551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16551 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09835 from Sigma-Aldrich
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PDGFB siRNA (Human) - CRH3435 from Cohesion Biosciences
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PDGF-B RNAi - H00005155-R01 from Novus Biologicals
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PDGF-B CRISPR/Cas9 KO Plasmid (h2) - sc-400586-KO-2 from Santa Cruz Biotechnology
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PDGF-B HDR Plasmid (h2) - sc-400586-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PDGFB (NM_002608.2) - SHH372648 from Creative biogene
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PDGFB shRNA Plasmid (Human) - CHH3435 from Cohesion Biosciences
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PDGFB miRNA 3'UTR clone - MiUTR3H-02270 from Creative biogene
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PDGFB miRNA 3'UTR clone - MiUTR3H-02271 from Creative biogene
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