| Gene Symbol |
MX2
|
| Entrez Gene |
4600
|
| Alt Symbol |
MXB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MX dynamin-like GTPase 2
|
| Other Description |
interferon-induced GTP-binding protein Mx2|interferon-regulated resistance GTP-binding protein MXB|myxovirus (influenza virus) resistance 2|myxovirus resistance protein 2|p78-related protein|second interferon-induced protein p78
|
| Swissprots |
B7Z5D3 D3DSI7 P20592
|
| Accessions |
AAC08448 AAC08451 CAB90555 EAX09605 EAX09606 EAX09607 P20592 AK122952 AK124336 AK127895 AK298780 BAH12869 AK308060 AY312582 BC035293 AAH35293 DQ892116 ABM83042 DQ895311 ABM86237 M30818 AAA36338 M33883 AAA36459 XM_005260983 XP_005261040 XM_005260984 XP_005261041 XM_011529571 XP_011527873 XM_011529572 XP_011527874 XM_011529573 XP_011527875 XM_011529574 XP_011527876 NM_002463 NP_002454
|
| Function |
Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.
|