Gene Symbol | MX2 |
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Entrez Gene | 4600 |
Alt Symbol | MXB |
Species | Human |
Gene Type | protein-coding |
Description | MX dynamin-like GTPase 2 |
Other Description | interferon-induced GTP-binding protein Mx2|interferon-regulated resistance GTP-binding protein MXB|myxovirus (influenza virus) resistance 2|myxovirus resistance protein 2|p78-related protein|second interferon-induced protein p78 |
Swissprots | B7Z5D3 D3DSI7 P20592 |
Accessions | AAC08448 AAC08451 CAB90555 EAX09605 EAX09606 EAX09607 P20592 AK122952 AK124336 AK127895 AK298780 BAH12869 AK308060 AY312582 BC035293 AAH35293 DQ892116 ABM83042 DQ895311 ABM86237 M30818 AAA36338 M33883 AAA36459 XM_005260983 XP_005261040 XM_005260984 XP_005261041 XM_011529571 XP_011527873 XM_011529572 XP_011527874 XM_011529573 XP_011527875 XM_011529574 XP_011527876 NM_002463 NP_002454 |
Function | Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding. |
Human MX2 protein fragment - ab114903 from Abcam
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Human MX2 protein fragment - ab177616 from Abcam
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MX2 Partial Recombinant Protein - H00004600-Q01 from Novus Biologicals
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MX2 protein (His tag) - 80R-3647 from Fitzgerald
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MX2 Blocking Peptide - abx062967 from Abbexa
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MX2 (626-715, His-tag) - AR51334PU-N from Acris Antibodies
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MX2 (626-715, His-tag) - AR51334PU-S from Acris Antibodies
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MX2 - H00004600-Q01-10 from Acris Antibodies
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MX2 - H00004600-Q01-25 from Acris Antibodies
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MX2, 626-715aa, Human, His tag, E.coli - 01-P2514 from ARP American Research Products
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MX2 fusion protein - Ag4020 from Proteintech Group
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MX2, 626-715aa, Human, His tag, E.coli - GWB-ATG02E from Genway Biotech
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Recombinant Human MX2 - MX2-30264TH from Creative Biomart
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Recombinant Human MX2, His-tagged - MX2-5018H from Creative Biomart
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Recombinant Human myxovirus (influenza virus) resistance 2 (mouse), His-tagged - MX2-417H from Creative Biomart
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Recombinant Myxovirus Resistance 2 (MX2) - RPL764Hu01 from Uscn Life Science Inc.
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MX2 Blocking Peptide - CBP1773 from Cohesion Biosciences
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MX2 Peptide - BS5805P from Bioworld Technology
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Recombinant Myxovirus Resistance 2 (MX2) - RPL764Hu01 from Cloud-clone
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Recombinant Human Interferon-induced GTP-binding protein Mx2(MX2) - CSB-YP015250HU CSB-EP015250HU CSB-BP015250HU CSB-MP015250HU from Cusabio
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MX2, 626-715aa, Human, His tag, E.coli (Denatured) - ATGP2514 from ATGen
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MX2 - TP306437 from Acris Antibodies
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Human MX2 protein - orb259976 from Biorbyt
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MX2 Recombinant Protein Antigen - NBP1-81018PEP from Novus Biologicals
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MX2 Peptide, Human - M34GP09954H from Creative Peptides
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