GFER

Gene Symbol GFER
Entrez Gene 2671
Alt Symbol ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS
Species Human
Gene Type protein-coding
Description growth factor, augmenter of liver regeneration
Other Description ERV1 homolog|FAD-linked sulfhydryl oxidase ALR|erv1-like growth factor|hepatic regenerative stimulation substance|hepatopoietin protein
Swissprots Q9H290 Q53YM6 Q9UK40 Q8TAH6 P55789
Accessions AAD36986 AAD56538 AAK51609 CAB87993 EAW85578 EAW85579 EAW85580 P55789 AF124603 AAD17327 AF124604 AAD17328 AF208342 AAG43494 AF306863 AAG38105 AY550027 AAS55642 BC002429 AAH02429 BC028348 AAH28348 BG705583 U31176 AAA96390 NM_005262 NP_005253
Function Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.
Subcellular Location Isoform 1: Mitochondrion intermembrane space.
Tissue Specificity Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. {ECO:0000269|PubMed:19409522}.

ALR (C-3) - sc-365886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALR (C-3): sc-365886. Western blot analysis of ALR expression in non-transfected: sc-117752 (A) and mouse ALR transfected: sc-118366 (B) 293T whole cell lysates.

ALR (E-7) - sc-365885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ALR (E-7): sc-365885. Western blot analysis of ALR expression in non-transfected: sc-117752 (A) and mouse ALR transfected: sc-118366 (B) 293T whole cell lysates.

ALR (E-15) - sc-51254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ALR (FL-205) - sc-134869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ALR (FL-205): sc-134869. Western blot analysis of ALR expression in non-transfected: sc-117752 (A) and mouse ALR transfected: sc-118366 (B) 293T whole cell lysates.

ALR (V-16) - sc-51257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALR (V-16): sc-51257. Western blot analysis of ALR expression in Hep G2 whole cell lysate (A) and rat liver (B) and mouse liver (C) tissue extracts.

Anti-ALR antibody - ab36376 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ALR antibody (ab36376) at 1 µg/mlLane 1 : Liver (Mouse) Tissue LysateLane 2 : Testis (Mouse) Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

Anti-ALR antibody - ab196498 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ALR antibody (ab196498) at 1/500 dilutionLane 1 : MCF7 cell lysateLane 2 : 293T cell lysateLane 3 : HepG2 cell lysate

Anti-ALR antibody - ab36487 from Abcam

Prices $242.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab36487 stained human HepG2 cells. The cells were 4% PFA fixed (10 min), permabilised in 0.1% PBS-Tween (20 min) and incubated with the antibody (ab36487, 5µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue). This antibody also gave a positive IF result in HeLa, HEK 293 and MCF7 cells.  However, this Fast-Track antibody is not yet fully characterised.  This image represents inconclusive preliminary data.

Anti-ALR antibody - ab170260 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ALR antibody (ab170260) at 1/100 dilution + HepG2 cell line lysate at 35 µg

Anti-ALR antibody - C-terminal - ab170507 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow Cytometric analysis of HepG2 cells labeling ALR with ab170507 at 1/10 dilution (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Anti-GFER Antibody (aa67-94, AP) - LS-C257677 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (aa67-94, Biotin) - LS-C257679 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (aa67-94, APC) - LS-C257678 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (aa67-94, PE) - LS-C257682 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (aa67-94, Azide-free, HRP) - LS-C257681 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (aa67-94, FITC) - LS-C257680 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (aa74-103) - LS-C321606 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody - LS-C341801 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GFER Antibody (C-Terminus) - LS-C345582 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of ALR Antibody with human Fetal Kidney lysate.

Anti-GFER Antibody (aa173-202) - LS-C166441 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GFER Antibody western blot of mouse NIH-3T3 cell line lysates (35 ug/lane). The GFER antibody detected the GFER protein (arrow).

Anti-GFER Antibody - LS-C334073 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using GFER antibody.

Anti-GFER Antibody (aa67-94) - LS-C166442 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GFER Antibody western blot of HepG2 cell line lysates (35 ug/lane). The GFER antibody detected the GFER protein (arrow).

GFER/ALR Antibody (829812) - MAB7940 from Novus Biologicals

Prices $249.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 829812
Western Blot GFER/ALR Antibody (829812)

GFER/ALR Antibody - NBP1-90187 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GFER/ALR Antibody [NBP1-90187] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

ANTI-GFER (CENTER) antibody produced in rabbit - SAB1304975 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-GFER (Center): <B>Cat. No. SAB1304975 </B>: GFER Antibody (Center) western blot analysis in HepG2 cell line lysates (35 μg/lane).
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