Gene Symbol | GFER |
---|---|
Entrez Gene | 2671 |
Alt Symbol | ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS |
Species | Human |
Gene Type | protein-coding |
Description | growth factor, augmenter of liver regeneration |
Other Description | ERV1 homolog|FAD-linked sulfhydryl oxidase ALR|erv1-like growth factor|hepatic regenerative stimulation substance|hepatopoietin protein |
Swissprots | Q9H290 Q53YM6 Q9UK40 Q8TAH6 P55789 |
Accessions | AAD36986 AAD56538 AAK51609 CAB87993 EAW85578 EAW85579 EAW85580 P55789 AF124603 AAD17327 AF124604 AAD17328 AF208342 AAG43494 AF306863 AAG38105 AY550027 AAS55642 BC002429 AAH02429 BC028348 AAH28348 BG705583 U31176 AAA96390 NM_005262 NP_005253 |
Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen. |
Subcellular Location | Isoform 1: Mitochondrion intermembrane space. |
Tissue Specificity | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. {ECO:0000269|PubMed:19409522}. |