Gene Symbol | GFER |
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Entrez Gene | 2671 |
Alt Symbol | ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS |
Species | Human |
Gene Type | protein-coding |
Description | growth factor, augmenter of liver regeneration |
Other Description | ERV1 homolog|FAD-linked sulfhydryl oxidase ALR|erv1-like growth factor|hepatic regenerative stimulation substance|hepatopoietin protein |
Swissprots | Q9H290 Q53YM6 Q9UK40 Q8TAH6 P55789 |
Accessions | AAD36986 AAD56538 AAK51609 CAB87993 EAW85578 EAW85579 EAW85580 P55789 AF124603 AAD17327 AF124604 AAD17328 AF208342 AAG43494 AF306863 AAG38105 AY550027 AAS55642 BC002429 AAH02429 BC028348 AAH28348 BG705583 U31176 AAA96390 NM_005262 NP_005253 |
Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen. |
Subcellular Location | Isoform 1: Mitochondrion intermembrane space. |
Tissue Specificity | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. {ECO:0000269|PubMed:19409522}. |
Human ALR full length protein - ab114811 from Abcam
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Human ALR full length protein - ab139218 from Abcam
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Human ALR peptide - ab36485 from Abcam
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Human ALR protein fragment - ab179961 from Abcam
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GFER Antibody Blocking Peptide - LS-E830 from LifeSpan Bioscience
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GFER Antibody Blocking Peptide - LS-E1143 from LifeSpan Bioscience
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GFER/ALR Recombinant Protein - H00002671-P01 from Novus Biologicals
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Recombinant Human GFER/ALR Protein - NBP2-23090 from Novus Biologicals
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GFER-Antibody-Center-Blocking-peptide - BP11198c from Abgent, a WuXi AppTec company
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GFER-Antibody-C-term-Blocking-peptide - BP11673b from Abgent, a WuXi AppTec company
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Human GFER protein (His Tag) - orb138912 from Biorbyt
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Human GFER protein - orb168388 from Biorbyt
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GFER protein (His tag) - 30R-2926 from Fitzgerald
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Hepatopoietin (1-205, His-tag) - AR50686PU-N from Acris Antibodies
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Hepatopoietin (1-205, His-tag) - AR50686PU-S from Acris Antibodies
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Hepatopoietin - H00002671-P01-10 from Acris Antibodies
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Hepatopoietin - H00002671-P01-25 from Acris Antibodies
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GFER, 1-205aa, Human, His tag, E.coli - 01-P1862 from ARP American Research Products
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GFER Recombinant Protein (HEK293 Expressed) - 96-348 from ProSci
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GFER Recombinant Protein (Mass Spec Standard (C13 and N15-labeled)) - 96-349 from ProSci
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GFER fusion protein - ag1840 from Proteintech Group
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GFER Human - PRPS-1333 from NeoScientific
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Human GFER Recombinant Protein - GWB-PPAT24 from Genway Biotech
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Recombinant Human GFER - GFER-27232TH from Creative Biomart
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Recombinant Human GFER, His-tagged - GFER-7080H from Creative Biomart
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