| Gene Symbol |
GFER
|
| Entrez Gene |
2671
|
| Alt Symbol |
ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth factor, augmenter of liver regeneration
|
| Other Description |
ERV1 homolog|FAD-linked sulfhydryl oxidase ALR|erv1-like growth factor|hepatic regenerative stimulation substance|hepatopoietin protein
|
| Swissprots |
Q9H290 Q53YM6 Q9UK40 Q8TAH6 P55789
|
| Accessions |
AAD36986 AAD56538 AAK51609 CAB87993 EAW85578 EAW85579 EAW85580 P55789 AF124603 AAD17327 AF124604 AAD17328 AF208342 AAG43494 AF306863 AAG38105 AY550027 AAS55642 BC002429 AAH02429 BC028348 AAH28348 BG705583 U31176 AAA96390 NM_005262 NP_005253
|
| Function |
Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.
|
| Subcellular Location |
Isoform 1: Mitochondrion intermembrane space.
|
| Tissue Specificity |
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. {ECO:0000269|PubMed:19409522}.
|