Gene Symbol | GFER |
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Entrez Gene | 2671 |
Alt Symbol | ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS |
Species | Human |
Gene Type | protein-coding |
Description | growth factor, augmenter of liver regeneration |
Other Description | ERV1 homolog|FAD-linked sulfhydryl oxidase ALR|erv1-like growth factor|hepatic regenerative stimulation substance|hepatopoietin protein |
Swissprots | Q9H290 Q53YM6 Q9UK40 Q8TAH6 P55789 |
Accessions | AAD36986 AAD56538 AAK51609 CAB87993 EAW85578 EAW85579 EAW85580 P55789 AF124603 AAD17327 AF124604 AAD17328 AF208342 AAG43494 AF306863 AAG38105 AY550027 AAS55642 BC002429 AAH02429 BC028348 AAH28348 BG705583 U31176 AAA96390 NM_005262 NP_005253 |
Function | Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen. |
Subcellular Location | Isoform 1: Mitochondrion intermembrane space. |
Tissue Specificity | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle. {ECO:0000269|PubMed:19409522}. |
ALR CRISPR/Cas9 KO Plasmid (h) - sc-403367 from Santa Cruz Biotechnology
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ALR HDR Plasmid (h) - sc-403367-HDR from Santa Cruz Biotechnology
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ALR Double Nickase Plasmid (h) - sc-403367-NIC from Santa Cruz Biotechnology
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ALR Double Nickase Plasmid (h2) - sc-403367-NIC-2 from Santa Cruz Biotechnology
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ALR CRISPR Activation Plasmid (h) - sc-403367-ACT from Santa Cruz Biotechnology
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ALR CRISPR Activation Plasmid (h2) - sc-403367-ACT-2 from Santa Cruz Biotechnology
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ALR Lentiviral Activation Particles (h) - sc-403367-LAC from Santa Cruz Biotechnology
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ALR Lentiviral Activation Particles (h2) - sc-403367-LAC-2 from Santa Cruz Biotechnology
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ALR siRNA (h) - sc-72224 from Santa Cruz Biotechnology
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ALR shRNA Plasmid (h) - sc-72224-SH from Santa Cruz Biotechnology
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ALR shRNA (h) Lentiviral Particles - sc-72224-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9238 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9238 from Sigma-Aldrich
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GFER siRNA (Human) - CRH1780 from Cohesion Biosciences
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GFER - MBS8208641 from MyBioSource
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ALR CRISPR/Cas9 KO Plasmid (h2) - sc-403367-KO-2 from Santa Cruz Biotechnology
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ALR HDR Plasmid (h2) - sc-403367-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human GFER (NM_005262.2) - SHH300554 from Creative biogene
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shRNA set against Human GFER(NM_005262.2) - SHH082217 from Creative biogene
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GFER shRNA Plasmid (Human) - CHH1780 from Cohesion Biosciences
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GFER miRNA 3'UTR clone - MiUTR1H-04010 from Creative biogene
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