| Gene Symbol |
AIMP1
|
| Entrez Gene |
9255
|
| Alt Symbol |
EMAP2, EMAPII, HLD3, SCYE1, p43
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
|
| Other Description |
ARS-interacting multifunctional protein 1|aminoacyl tRNA synthase complex-interacting multifunctional protein 1|endothelial monocyte-activating polypeptide 2|endothelial-monocyte activating polypeptide II|multisynthase complex auxiliary component p43|multisynthetase complex auxiliary component p43|small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
|
| Swissprots |
Q6FG28 B4E1S7 Q12904 Q96CQ9 B3KTR2
|
| Accessions |
EAX06203 EAX06204 Q12904 AK095951 BAG53174 AK297950 BAG60265 AK303965 BAG64889 AY527272 BC014051 AAH14051 BG941396 BI258927 BM314663 BQ447202 CR542281 CAG47076 DA211424 DC358150 DQ893299 ABM84225 DQ896737 ABM87736 U10117 AAA62202 NM_001142415 NP_001135887 NM_001142416 NP_001135888 NM_004757 NP_004748
|
| Function |
Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:1223731
|
| Subcellular Location |
Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.
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