AIMP1

Gene Symbol	AIMP1
Entrez Gene	9255
Alt Symbol	EMAP2, EMAPII, HLD3, SCYE1, p43
Species	Human
Gene Type	protein-coding
Description	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Other Description	ARS-interacting multifunctional protein 1|aminoacyl tRNA synthase complex-interacting multifunctional protein 1|endothelial monocyte-activating polypeptide 2|endothelial-monocyte activating polypeptide II|multisynthase complex auxiliary component p43|multisynthetase complex auxiliary component p43|small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Swissprots	Q6FG28 B4E1S7 Q12904 Q96CQ9 B3KTR2
Accessions	EAX06203 EAX06204 Q12904 AK095951 BAG53174 AK297950 BAG60265 AK303965 BAG64889 AY527272 BC014051 AAH14051 BG941396 BI258927 BM314663 BQ447202 CR542281 CAG47076 DA211424 DC358150 DQ893299 ABM84225 DQ896737 ABM87736 U10117 AAA62202 NM_001142415 NP_001135887 NM_001142416 NP_001135888 NM_004757 NP_004748
Function	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:1223731
Subcellular Location	Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human AIMP1 cDNA clone(NM_001142415.1) - CDFH000534 from Creative Biomart Species Human Accession NM_001142415.1

Human AIMP1 cDNA clone(NM_001142416.1) - CDFH000535 from Creative Biomart Species Human Accession NM_001142416.1

Human AIMP1 ORF clone(NM_004757.3) - CDCH015309 from Creative Biomart Species Human Accession NM_004757.3

Human AIMP1 ORF Clone(NM_001142415.1) - CDCR351257 from Creative Biomart Species Human Accession NM_001142415.1

Human AIMP1 ORF Clone(NM_001142415.1) - CDCR351258 from Creative Biomart Species Human Accession NM_001142415.1

Human AIMP1 ORF Clone(NM_001142416.1) - CDCR351260 from Creative Biomart Species Human Accession NM_001142416.1

Human AIMP1 ORF Clone(NM_001142416.1) - CDCR351267 from Creative Biomart Species Human Accession NM_001142416.1

Human SCYE1 ORF Clone(NM_004757.3) - CDCL174748 from Creative Biomart Species Human Accession NM_004757.3

Human AIMP1/EMAP II Gene ORF cDNA clone in cloning vector - HG10623-M from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10623-NF from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10623-NM from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-HA tag - HG10623-CY from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10623-M-F from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10623-CF from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10623-CM from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, N-HA tag - HG10623-NY from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-His tag - HG10623-CH from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10623-ACR from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10623-ANR from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10623-ANG from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid - HG10623-UT from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid - HG10623-M-N from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10623-ACG from Sino Biological Species Human

Human AIMP1/EMAP II Gene ORF cDNA clone expression plasmid, N-His tag - HG10623-NH from Sino Biological Species Human

AIMP1/SCYE1 - CL01108H01 from Elabscience Species Human Accession NM_001142415.1

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