AIMP1

Gene Symbol AIMP1
Entrez Gene 9255
Alt Symbol EMAP2, EMAPII, HLD3, SCYE1, p43
Species Human
Gene Type protein-coding
Description aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Other Description ARS-interacting multifunctional protein 1|aminoacyl tRNA synthase complex-interacting multifunctional protein 1|endothelial monocyte-activating polypeptide 2|endothelial-monocyte activating polypeptide II|multisynthase complex auxiliary component p43|multisynthetase complex auxiliary component p43|small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Swissprots Q6FG28 B4E1S7 Q12904 Q96CQ9 B3KTR2
Accessions EAX06203 EAX06204 Q12904 AK095951 BAG53174 AK297950 BAG60265 AK303965 BAG64889 AY527272 BC014051 AAH14051 BG941396 BI258927 BM314663 BQ447202 CR542281 CAG47076 DA211424 DC358150 DQ893299 ABM84225 DQ896737 ABM87736 U10117 AAA62202 NM_001142415 NP_001135887 NM_001142416 NP_001135888 NM_004757 NP_004748
Function Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:1223731
Subcellular Location Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.

EMAP II (A-4) - sc-393228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMAP II (A-4): sc-393228. Western blot analysis of EMAP II expression in non-transfected 293T: sc-117752 (A), mouse EMAP II transfected 293T: sc-120016 (B), U-937 (C) and RAW 264.7 (D) whole cell lysates.

EMAP II (A-10) - sc-393672 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMAP II (A-10): sc-393672. Western blot analysis of EMAP II expression in non-transfected 293T: sc-117752 (A), mouse EMAP II transfected 293T: sc-120016 (B), RAW 264.7 (C), WEHI-231 (D), THP-1 (E) and U-937 (F) whole cell lysates.

EMAP II (E-5) - sc-393733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMAP II (E-5): sc-393733. Western blot analysis of EMAP II expression in non-transfected 293T: sc-117752 (A), mouse EMAP II transfected 293T: sc-120016 (B), RAW 264.7 (C) and THP-1 (D) whole cell lysates.

EMAP II (G-2) - sc-271115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMAP II (G-2): sc-271115. Western blot analysis of EMAP II expression in THP-1 (A), U-937 (B), T98G (C) and KNRK (D) whole cell lysates.

EMAP II (546-2) - sc-32723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMAP II (546-2) PE: sc-32723 PE. Intracellular FCM analysis of fixed and permeabilized BJAB cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>, sc-2868.

EMAP II (18) - sc-136383 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMAP II (18): sc-136383. Western blot analysis of EMAP II expression in HCT-8 whole cell lysate.

EMAP II (C-17) - sc-27564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EMAP II (C-17): sc-27564. Immunofluorescence staining of methanol-fixed WEHI-231 cells showing cytoplasmic localization.

EMAP II (H-92) - sc-66879 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EMAP II (H-92): sc-66879. Western blot analysis of EMAP II expression in UV treated HeLa (A), T98G (B) and HT-1080 (C) whole cell lysates.

Anti-EMAP II antibody - ab96506 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EMAP II antibody (ab96506) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-EMAP II antibody - ab139118 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
ab139118 (5µg/ml) staining of paraffin embedded Human Pancreas following steamed antigen retrieval with citrate buffer pH 6 and AP-staining shows staining in the cytoplasm towards the alpha cells periphery.

Anti-EMAP II antibody - ab89506 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-EMAP II antibody (ab89506) at 5 µg/ml + Jurkat cell lysate at 50 µg

Anti-EMAP II antibody - ab109610 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-EMAP II antibody - ab26119 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-EMAP II antibody - ab105756 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-EMAP II antibody (ab105756) at 1/5000 dilution + HEK293 cell lysate

Anti-EMAP II antibody [284D2a] - ab54357 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 284D2a
Anti-EMAP II antibody [284D2a] (ab54357) + immunising recombinant protein fragment.

Anti-EMAP II antibody [546-2] - ab15693 from Abcam

Prices $380.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 546-2
Lanes 1, 2, 3, 4, 6, 7, 8 & 9 : Anti-EMAP II antibody [546-2] (ab15693) at 1/1000 dilutionLane 5 : Lane 10 : Lane 1 : HeLa Cytoplasmic Extract (0.625ug)Lane 2 : HeLa Cytoplasmic Extract (1.25ug)Lane 3 : HeLa Cytoplasmic Extract (2.5ug)Lane 4 : HeLa Cytoplasmic Extract (5ug)Lane 5 : High Range Rainbow MWMsLane 6 : HeLa Nuclear Extract (0.625ug)Lane 7 : HeLa Nuclear Extract (1.25ug)Lane 8 : HeLa Nuclear Extract (2.5ug)Lane 9 : HeLa Nuclear Extract (5ug)Lane 10 : High Range Rainbow MWMsSecondaryLanes 1, 2, 3, 4, 6, 7, 8 & 9 : HRP conjugated Sheep anti-mouse IgG

Anti-EMAP II antibody (Biotin) - ab83518 from Abcam

Prices $370.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-EMAP II antibody [EPR14168(B)] - ab188320 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14168(B)
All lanes : Anti-EMAP II antibody [EPR14168(B)] (ab188320) at 1/5000 dilutionLane 1 : HT-1080 cell lysateLane 2 : HeLa cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-EMAP II antibody - C-terminal - ab180893 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-EMAP II antibody - C-terminal (ab180893) at 0.5 µg/mlLane 2 : Anti-EMAP II antibody - C-terminal (ab180893) at 1 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat brain tissue lysateLysates/proteins at 15 µg per lane.

Anti-EMAP II antibody - C-terminal - ab175528 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human lymphnode labeling EMAPII with ab175528 at 1/50 followed by peroxidase conjugation of the secondary antibody and DAB staining.

Anti-EMAP II antibody - N-terminal - ab139103 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-EMAP II antibody - N-terminal (ab139103) at 0.3 µg/ml + Jurkat cell lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-AIMP1 / EMAP II Antibody - LS-C75876 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-AIMP1 / EMAP II Antibody (clone 546-2) - LS-C96273 from LifeSpan Bioscience

Prices $590.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 546-2

Anti-AIMP1 / EMAP II Antibody (Biotin) - LS-C104511 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Goat
Clonality Polyclonal

Anti-AIMP1 / EMAP II / p43 Antibody - LS-C128730 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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