AIMP1

Gene Symbol	AIMP1
Entrez Gene	9255
Alt Symbol	EMAP2, EMAPII, HLD3, SCYE1, p43
Species	Human
Gene Type	protein-coding
Description	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Other Description	ARS-interacting multifunctional protein 1|aminoacyl tRNA synthase complex-interacting multifunctional protein 1|endothelial monocyte-activating polypeptide 2|endothelial-monocyte activating polypeptide II|multisynthase complex auxiliary component p43|multisynthetase complex auxiliary component p43|small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)
Swissprots	Q6FG28 B4E1S7 Q12904 Q96CQ9 B3KTR2
Accessions	EAX06203 EAX06204 Q12904 AK095951 BAG53174 AK297950 BAG60265 AK303965 BAG64889 AY527272 BC014051 AAH14051 BG941396 BI258927 BM314663 BQ447202 CR542281 CAG47076 DA211424 DC358150 DQ893299 ABM84225 DQ896737 ABM87736 U10117 AAA62202 NM_001142415 NP_001135887 NM_001142416 NP_001135888 NM_004757 NP_004748
Function	Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. {ECO:0000269|PubMed:10358004, ECO:0000269|PubMed:11157763, ECO:0000269|PubMed:11306575, ECO:0000269|PubMed:11818442, ECO:0000269|PubMed:1223731
Subcellular Location	Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human EMAP II full length protein - ab199808 from Abcam Category Protein Prices $99.00 Sizes 5 µg Source E. coli Species Human

Human EMAP II full length protein - ab185580 from Abcam Category Protein Source E. coli Species Human

Human EMAP II full length protein - ab101823 from Abcam Category Protein Source E. coli Species Human

AIMP1 / EMAP II Antibody Blocking Peptide - LS-E14818 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIMP1 / EMAP II Antibody Blocking Peptide - LS-E14819 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIMP1 / EMAP II Antibody Blocking Peptide - LS-E8416 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIMP1 / EMAP II Antibody Blocking Peptide - LS-E27886 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AIMP1 / EMAP II Antibody Blocking Peptide - LS-E27887 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EMAP-II/AIMP1 Recombinant Protein - H00009255-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human EMAP-II/AIMP1 Protein - P3601 from Novus Biologicals Category Protein Prices $369.00 Sizes 20 µg Source E. coli Species Human

Recombinant Human EMAP-II/AIMP1 Protein - NBP1-99382 from Novus Biologicals Category Protein Prices $190.00 Sizes 20 µg Source E. coli Species Human

Recombinant Human EMAP-II/AIMP1 Protein - NBP1-50936 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

MCA1-Antibody-C-term-Blocking-Peptide - BP6721b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EMAP II recombinant protein - GTX65302 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source E. coli Species Human

EML2/ELP70 blocking peptide - GTX15940-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

EML5 blocking peptide - GTX88297-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

EMAP II Protein (OPPA01617) - OPPA01617 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human AIMP1 His tag protein - orb83698 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human AIMP1 protein - orb167869 from Biorbyt Category Protein Prices $230.00, $442.00, $1,811.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli Species Human

AIMP1 protein (His tag) - 80R-1611 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

EMAP II protein - 30R-2604 from Fitzgerald Category Protein Prices $245.00 Sizes 20 µg Source E.coli Species Human

SCYE1 Blocking Peptide - 33R-5153 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SCYE1 Blocking Peptide - 33R-3610 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human AIMP1 Protein - abx065290 from Abbexa Category Protein Source E.coli Species Human

EMAP II Peptide - AC21-2670-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

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