EXO5

Gene Symbol EXO5
Entrez Gene 64789
Alt Symbol C1orf176, DEM1, Exo V, hExo5
Species Human
Gene Type protein-coding
Description exonuclease 5
Other Description defects in morphology 1 homolog|defects in morphology protein 1 homolog|exonuclease V|probable exonuclease V
Swissprots Q5SWN1 Q5SWM9 Q5SWM8 D3DPV4 Q9H790 Q8WTW9 Q5SWM7 Q5SWN0
Accessions EAX07210 EAX07211 EAX07212 EAX07213 EAX07214 Q9H790 AF086542 AK021507 AK023245 AK024797 BAB15008 AK094092 BC021969 AAH21969 HQ448143 ADQ32624 XM_005271125 XP_005271182 XM_005271126 XP_005271183 XM_005271128 XP_005271185 XM_011541970 XP_011540272 NM_022774 NP_073611
Function Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269|PubMed:23095756}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.

DEM1 (P-17) - sc-246423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DEM1 antibody - ab107680 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DEM1 antibody (ab107680) at 1/100 dilution + MDA-MB435 cell lysate at 35 µg

Anti-DEM1 antibody - C-terminal - ab136314 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DEM1 antibody - C-terminal (ab136314) at 1 µg/ml + Human placenta lysate at 10 µgSecondaryGoat anti-rabbit IgG HRPdeveloped using the ECL technique

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193) - LS-C167355 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DEM1 Antibody western blot of mouse NIH-3T3 cell line lysates (35 ug/lane). The DEM1 antibody detected the DEM1 protein (arrow).

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193, AP) - LS-C213543 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193, Biotin) - LS-C213544 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193, APC) - LS-C213545 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193, Azide-free, HRP) - LS-C213546 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193, FITC) - LS-C213547 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa173-201) - LS-C320805 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa166-193, PE) - LS-C213548 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EXO5 / Exonuclease 5 Antibody (aa202-251) - LS-C169817 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

DEM1 Antibody - NBP1-88493 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: DEM1 Antibody [NBP1-88493] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & cytoplasm.

Anti-DEM1 (326-340) antibody produced in rabbit - SAB1102169 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells (lane 1) and HeLa cells (lanes 2-3) were separated on SDS-PAGE, blotted with Anti-DEM1(326-340) (<B>Cat. No. SAB1102169</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:500<BR/>2. Antibody dilution 1:500<BR/>3. Antibody dilution 1:500 + DEM1 immunizing peptide (human, 326-340)

Anti-DEM1 (54-65) antibody produced in rabbit - SAB1102168 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human DEM1 was separated on SDS-PAGE, blotted with Anti-DEM1 (54-65) (<B>Cat. No. SAB1102168</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

DEM1 Antibody - C-terminal region (ARP66789_P050) - ARP66789_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DEM1 Antibody - middle region (OAAB00491) - OAAB00491 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

DEM1-Antibody-Center - AP10478c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
DEM1 Antibody (Center) (Cat. #AP10478c) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the DEM1 antibody detected the DEM1 protein (arrow).

Exonuclease 5 antibody - GTX53538 from GeneTex

Prices $319.00
Sizes 400 μl
Host Rabbit
Clonality Polyclonal
Anti-Exonuclease 5 antibody used in Flow cytometry/FACS. GTX53538
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