EXO5

Gene Symbol	EXO5
Entrez Gene	64789
Alt Symbol	C1orf176, DEM1, Exo V, hExo5
Species	Human
Gene Type	protein-coding
Description	exonuclease 5
Other Description	defects in morphology 1 homolog|defects in morphology protein 1 homolog|exonuclease V|probable exonuclease V
Swissprots	Q5SWN1 Q5SWM9 Q5SWM8 D3DPV4 Q9H790 Q8WTW9 Q5SWM7 Q5SWN0
Accessions	EAX07210 EAX07211 EAX07212 EAX07213 EAX07214 Q9H790 AF086542 AK021507 AK023245 AK024797 BAB15008 AK094092 BC021969 AAH21969 HQ448143 ADQ32624 XM_005271125 XP_005271182 XM_005271126 XP_005271183 XM_005271128 XP_005271185 XM_011541970 XP_011540272 NM_022774 NP_073611
Function	Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269|PubMed:23095756}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EXO5 Gene cDNA Clone - orb143095 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-DEM1-cDNA-Clone - DC05154 from Abgent, a WuXi AppTec company Prices $504.90 Sizes 10 µg Species Human Accession BC021969

DEM1 - MBS1265685 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC021969

Human DEM1 ORF clone (NM_022774.1) - CDCR054882 from Creative biogene Species Human

Human DEM1 ORF Clone (BC021969) - CDCS415554 from Creative biogene Species Human Accession Q9H790

Human EXO5 ORF clone (BC021969) - CDCB158063 from Creative biogene Species Human

Human DEM1 cDNA Clone(NM_022774.1) - CDFG003941 from Creative biogene Species Human

Human DEM1 cDNA Clone(NM_022774.1) - CDFG003944 from Creative biogene Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15535-ACG from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15535-CM from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15535-NM from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid - HG15535-UT from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, N-His tag - HG15535-NH from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15535-ACR from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15535-ANR from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15535-NY from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15535-CY from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15535-ANG from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, C-His tag - HG15535-CH from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15535-NF from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15535-CF from Sino Biological Species Human

Human Exonuclease 5 Gene ORF cDNA clone in cloning vector - HG15535-G from Sino Biological Species Human

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