| Gene Symbol |
EXO5
|
| Entrez Gene |
64789
|
| Alt Symbol |
C1orf176, DEM1, Exo V, hExo5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
exonuclease 5
|
| Other Description |
defects in morphology 1 homolog|defects in morphology protein 1 homolog|exonuclease V|probable exonuclease V
|
| Swissprots |
Q5SWN1 Q5SWM9 Q5SWM8 D3DPV4 Q9H790 Q8WTW9 Q5SWM7 Q5SWN0
|
| Accessions |
EAX07210 EAX07211 EAX07212 EAX07213 EAX07214 Q9H790 AF086542 AK021507 AK023245 AK024797 BAB15008 AK094092 BC021969 AAH21969 HQ448143 ADQ32624 XM_005271125 XP_005271182 XM_005271126 XP_005271183 XM_005271128 XP_005271185 XM_011541970 XP_011540272 NM_022774 NP_073611
|
| Function |
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269|PubMed:23095756}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.
|
![Western Blot: DEM1 Overexpression Lysate (Adult Normal) [NBL1-08304] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DEM1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5775_DEM1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08304-img0002.jpg)