EXO5

Gene Symbol EXO5
Entrez Gene 64789
Alt Symbol C1orf176, DEM1, Exo V, hExo5
Species Human
Gene Type protein-coding
Description exonuclease 5
Other Description defects in morphology 1 homolog|defects in morphology protein 1 homolog|exonuclease V|probable exonuclease V
Swissprots Q5SWN1 Q5SWM9 Q5SWM8 D3DPV4 Q9H790 Q8WTW9 Q5SWM7 Q5SWN0
Accessions EAX07210 EAX07211 EAX07212 EAX07213 EAX07214 Q9H790 AF086542 AK021507 AK023245 AK024797 BAB15008 AK094092 BC021969 AAH21969 HQ448143 ADQ32624 XM_005271125 XP_005271182 XM_005271126 XP_005271183 XM_005271128 XP_005271185 XM_011541970 XP_011540272 NM_022774 NP_073611
Function Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269|PubMed:23095756}.
Subcellular Location Nucleus {ECO:0000269|PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269|PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.

DEM1 CRISPR/Cas9 KO Plasmid (h) - sc-413038 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 HDR Plasmid (h) - sc-413038-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 Double Nickase Plasmid (h) - sc-413038-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 Double Nickase Plasmid (h2) - sc-413038-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 CRISPR Activation Plasmid (h) - sc-413038-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 CRISPR Activation Plasmid (h2) - sc-413038-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 Lentiviral Activation Particles (h) - sc-413038-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 Lentiviral Activation Particles (h2) - sc-413038-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DEM1 siRNA (h) - sc-88243 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEM1 shRNA Plasmid (h) - sc-88243-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DEM1 shRNA (h) Lentiviral Particles - sc-88243-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU075991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7134 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7134 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07227 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07227

EXO5 siRNA (Human) - CRJ2094 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EXO5 - MBS8236593 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DEM1 (NM_022774.1) - SHH276993 from Creative biogene

Category siRNA
Species Reactivities Human

EXO5 shRNA Plasmid (Human) - CHJ2094 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EXO5 miRNA 3'UTR clone - MiUTR1H-01242 from Creative biogene

Species Reactivities Human
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