| Gene Symbol |
MMP14
|
| Entrez Gene |
4323
|
| Alt Symbol |
MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
matrix metallopeptidase 14 (membrane-inserted)
|
| Other Description |
matrix metalloproteinase-14|membrane type 1 metalloprotease|membrane-type-1 matrix metalloproteinase
|
| Swissprots |
Q92678 Q6GSF3 A8K5L0 P50281
|
| Accessions |
AAF24178 AAV40837 BAC53889 EAW66236 EAW66237 P50281 AK291325 BAF84014 AK312657 BAG35540 BC039581 BC064803 AAH64803 BQ009340 D26512 BAA05519 HE978355 CCK73138 HY075830 U41078 AAA83770 X83535 CAA58519 X90925 CAA62432 Z48481 CAA88372 NM_004995 NP_004986
|
| Function |
Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. {ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
|
| Tissue Specificity |
Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
|
| Top Pathways |
GnRH signaling pathway, TNF signaling pathway
|
![Western Blot: MMP14 Overexpression Lysate (Adult Normal) [NBL1-13153] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MMP14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26149_MMP14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13153-img0002.jpg)