MMP14

Gene Symbol	MMP14
Entrez Gene	4323
Alt Symbol	MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 14 (membrane-inserted)
Other Description	matrix metalloproteinase-14|membrane type 1 metalloprotease|membrane-type-1 matrix metalloproteinase
Swissprots	Q92678 Q6GSF3 A8K5L0 P50281
Accessions	AAF24178 AAV40837 BAC53889 EAW66236 EAW66237 P50281 AK291325 BAF84014 AK312657 BAG35540 BC039581 BC064803 AAH64803 BQ009340 D26512 BAA05519 HE978355 CCK73138 HY075830 U41078 AAA83770 X83535 CAA58519 X90925 CAA62432 Z48481 CAA88372 NM_004995 NP_004986
Function	Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. {ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Tissue Specificity	Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
Top Pathways	GnRH signaling pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MMP14 - MBS1277056 from MyBioSource Species Human Accession BC064803

Human MMP14 cDNA clone(NM_004995.2) - CDFH011589 from Creative Biomart Species Human Accession NM_004995.2

Human MMP14 ORF Clone(NM_004995.2) - CDCR289378 from Creative Biomart Species Human Accession NM_004995.2

Human MMP14 ORF Clone(NM_004995.2) - CDCR289379 from Creative Biomart Species Human Accession NM_004995.2

Human MMP14 ORF Clone(NM_004995.2) - CDCR289380 from Creative Biomart Species Human Accession NM_004995.2

Human MMP-14/MMP14 Gene ORF cDNA clone in cloning vector - HG10741-M from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10741-ACG from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10741-CM from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10741-NY from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, C-His tag - HG10741-CH from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10741-ACR from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid - HG10741-UT from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10741-NF from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, N-His tag - HG10741-NH from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10741-NM from Sino Biological Species Human

Human MMP-14 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10741-M-F from Sino Biological Species Human Accession NM_004995.2

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10741-CF from Sino Biological Species Human

Human MMP-14/MMP14 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10741-CY from Sino Biological Species Human

Human MMP-14 ORF clone(NM_004995.2) - CDCL185366 from Creative biogene Species Human

Human MMP14 ORF Clone (BC064803) - CDCS412050 from Creative biogene Species Human Accession P50281

Human MMP14 cDNA Clone(NM_004995.2) - CDFH011589 from Creative biogene Species Human

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