| Gene Symbol | MMP14 |
|---|---|
| Entrez Gene | 4323 |
| Alt Symbol | MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 14 (membrane-inserted) |
| Other Description | matrix metalloproteinase-14|membrane type 1 metalloprotease|membrane-type-1 matrix metalloproteinase |
| Swissprots | Q92678 Q6GSF3 A8K5L0 P50281 |
| Accessions | AAF24178 AAV40837 BAC53889 EAW66236 EAW66237 P50281 AK291325 BAF84014 AK312657 BAG35540 BC039581 BC064803 AAH64803 BQ009340 D26512 BAA05519 HE978355 CCK73138 HY075830 U41078 AAA83770 X83535 CAA58519 X90925 CAA62432 Z48481 CAA88372 NM_004995 NP_004986 |
| Function | Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. {ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm. |
| Tissue Specificity | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}. |
| Top Pathways | GnRH signaling pathway, TNF signaling pathway |
MT-MMP-1 CRISPR/Cas9 KO Plasmid (h) - sc-401028 from Santa Cruz Biotechnology
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MT-MMP-1 HDR Plasmid (h) - sc-401028-HDR from Santa Cruz Biotechnology
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MT-MMP-1 Double Nickase Plasmid (h) - sc-401028-NIC from Santa Cruz Biotechnology
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MT-MMP-1 Double Nickase Plasmid (h2) - sc-401028-NIC-2 from Santa Cruz Biotechnology
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MT-MMP-1 CRISPR Activation Plasmid (h) - sc-401028-ACT from Santa Cruz Biotechnology
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MT-MMP-1 CRISPR Activation Plasmid (h2) - sc-401028-ACT-2 from Santa Cruz Biotechnology
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MT-MMP-1 Lentiviral Activation Particles (h) - sc-401028-LAC from Santa Cruz Biotechnology
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MT-MMP-1 Lentiviral Activation Particles (h2) - sc-401028-LAC-2 from Santa Cruz Biotechnology
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MT-MMP-1 siRNA (h) - sc-41565 from Santa Cruz Biotechnology
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MT-MMP-1 shRNA Plasmid (h) - sc-41565-SH from Santa Cruz Biotechnology
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MT-MMP-1 shRNA (h) Lentiviral Particles - sc-41565-V from Santa Cruz Biotechnology
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MMP-14/MT1-MMP RNAi - H00004323-R01 from Novus Biologicals
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MISSION® esiRNA - EHU152001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1038 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1038 from Sigma-Aldrich
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MMP14 siRNA (Human) - CRH2935 from Cohesion Biosciences
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shRNA set against Human MMP14 (NM_004995.2) - SHH342912 from Creative biogene
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shRNA set against Human MMP14(NM_004995.2) - SHH193367 from Creative biogene
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Human MMP14 siRNA - orb263437 from Biorbyt
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MMP14 shRNA Plasmid (Human) - CHH2935 from Cohesion Biosciences
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MMP14 miRNA 3'UTR clone - MiUTR1H-06347 from Creative biogene
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