MMP14

Gene Symbol	MMP14
Entrez Gene	4323
Alt Symbol	MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, WNCHRS
Species	Human
Gene Type	protein-coding
Description	matrix metallopeptidase 14 (membrane-inserted)
Other Description	matrix metalloproteinase-14|membrane type 1 metalloprotease|membrane-type-1 matrix metalloproteinase
Swissprots	Q92678 Q6GSF3 A8K5L0 P50281
Accessions	AAF24178 AAV40837 BAC53889 EAW66236 EAW66237 P50281 AK291325 BAF84014 AK312657 BAG35540 BC039581 BC064803 AAH64803 BQ009340 D26512 BAA05519 HE978355 CCK73138 HY075830 U41078 AAA83770 X83535 CAA58519 X90925 CAA62432 Z48481 CAA88372 NM_004995 NP_004986
Function	Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. {ECO:0000269|PubMed:12714657, ECO:0000269|PubMed:20837484, ECO:0000269|PubMed:22065321}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Tissue Specificity	Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
Top Pathways	GnRH signaling pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MMP14 protein fragment - ab157068 from Abcam Category Protein Prices $883.00 Sizes 10 µg Source E. coli Species Human

Active human MMP14 protein fragment - ab168081 from Abcam Category Protein Prices $706.00 Sizes 10 µg Source E. coli Species Human

MMP-14 proenzyme - ab168877 from Abcam Prices $1,092.00 Sizes 10 µg Source E. coli Species Human

Human MMP14 full length protein - ab152534 from Abcam Category Protein Source Wheat germ Species Human

Human MMP14 peptide - ab98289 from Abcam Category Peptide

MMP14 peptide - ab41091 from Abcam Category Peptide

MMP14 peptide - ab41092 from Abcam Category Peptide

MMP14 peptide - ab41093 from Abcam Category Peptide

MMP14 peptide - ab44561 from Abcam Category Peptide

MMP14 peptide - ab185123 from Abcam Category Peptide

MMP14 Antibody Blocking Peptide - LS-E8125 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MMP14 Antibody Blocking Peptide - LS-E28050 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MMP-14/MT1-MMP Protein - H00004323-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MMP-14/MT1-MMP Peptide - P1806 from Novus Biologicals Category Peptide Species Human

Mouse-Mmp14-Antibody-C-term-Blocking-Peptide - BP19644b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Mouse

MMP14-Antibody-N-term-Blocking-Peptide - BP6198a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human MMP-14/MT1-MMP, CF - 918-MP-010 from R&D Systems Category Protein Source E. coli-derived, Ala21-Gly284, with a C-terminal 10-His tag

Recombinant Human MMP-14/MT1-MMP (NS0-expressed), CF - 918-MPN-010 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala21-Ser538, with an N-terminal human CD33 signal sequence, Arg108Pro mutation and a C-terminal 6-His tag

Human MMP14 protein - orb246394 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

MMP14 Blocking Peptide - abx062951 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

MMP14 Blocking Peptide - abx062952 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Pig, Rabbit

MMP14 Peptide - AC21-2920-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MMP-14 / MT1-MMP - AR05067PU-N from Acris Antibodies Category Protein Prices $550.00 Sizes 5 µg Source Human Species Human

MMP-14 / MT1-MMP - H00004323-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Matrix Metalloproteinase 14 (MMP14), Human - 20-8316 from ARP American Research Products Category Protein Prices $609.00 Sizes 50 µg Source E.coli Species Human

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