| Gene Symbol |
SUZ12
|
| Entrez Gene |
23512
|
| Alt Symbol |
CHET9, JJAZ1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SUZ12 polycomb repressive complex 2 subunit
|
| Other Description |
chET 9 protein|chromatin precipitated E2F target 9 protein|joined to JAZF1 protein|polycomb protein SUZ12|suppressor of zeste 12 homolog|suppressor of zeste 12 protein homolog
|
| Swissprots |
Q96BD9 Q15022
|
| Accessions |
EAW80258 Q15022 AK074333 AK290014 BAF82703 BC015704 AAH15704 BC018583 D63881 BAA09931 DB501687 ES313164 XM_005257954 XP_005258011 XM_006721794 XP_006721857 XM_011524576 XP_011522878 XM_011524577 XP_011522879 XM_011524578 XP_011522880 NM_015355 NP_056170
|
| Function |
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15231737}.
|
| Tissue Specificity |
Overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15684044}.
|