Gene Symbol | SUZ12 |
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Entrez Gene | 23512 |
Alt Symbol | CHET9, JJAZ1 |
Species | Human |
Gene Type | protein-coding |
Description | SUZ12 polycomb repressive complex 2 subunit |
Other Description | chET 9 protein|chromatin precipitated E2F target 9 protein|joined to JAZF1 protein|polycomb protein SUZ12|suppressor of zeste 12 homolog|suppressor of zeste 12 protein homolog |
Swissprots | Q96BD9 Q15022 |
Accessions | EAW80258 Q15022 AK074333 AK290014 BAF82703 BC015704 AAH15704 BC018583 D63881 BAA09931 DB501687 ES313164 XM_005257954 XP_005258011 XM_006721794 XP_006721857 XM_011524576 XP_011522878 XM_011524577 XP_011522879 XM_011524578 XP_011522880 NM_015355 NP_056170 |
Function | Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15231737}. |
Tissue Specificity | Overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15684044}. |
SUZ12 (D39F6) XP ® Rabbit mAb (Biotinylated) - 13701 from Cell Signaling Technology
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SUZ12 (D39F6) XP ® Rabbit mAb - 3737 from Cell Signaling Technology
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SUZ12 (P-15) - sc-46264 from Santa Cruz Biotechnology
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SUZ12 (D-10) - sc-271325 from Santa Cruz Biotechnology
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SUZ12 (G-18) - sc-46263 from Santa Cruz Biotechnology
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SUZ12 (H-300) - sc-67105 from Santa Cruz Biotechnology
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Anti-SUZ12 antibody - ab107249 from Abcam
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Anti-SUZ12 antibody - ab191573 from Abcam
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Anti-SUZ12 antibody - ab77605 from Abcam
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Anti-SUZ12 antibody [2C11] - ab107253 from Abcam
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Anti-SUZ12 antibody [EPR5234(N)] - ab175187 from Abcam
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Anti-SUZ12 antibody [EPR5234(N)] (Alexa Fluor® 647) - ab196975 from Abcam
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Anti-SUZ12 antibody [EPR5234(N)] (HRP) - ab196976 from Abcam
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Anti-SUZ12 antibody [SUZ220A] - ab126577 from Abcam
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Anti-SUZ12 antibody - ChIP Grade - ab12073 from Abcam
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Anti-SUZ12 antibody - N-terminal - ab135097 from Abcam
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Anti-SUZ12 Antibody (aa362-411) IHC-plus™ - LS-B5591 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (clone 3D10) IHC-plus™ - LS-B10727 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (aa131-305) - LS-C76167 from LifeSpan Bioscience
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Anti-SUZ12 Antibody - LS-C39346 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (aa559-588) - LS-C203831 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (aa689-739) - LS-C289153 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (C-Terminus) - LS-C80253 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (N-Terminus) - LS-C347706 from LifeSpan Bioscience
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Anti-SUZ12 Antibody (clone 2C11) - LS-C169292 from LifeSpan Bioscience
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