Gene Symbol | SUZ12 |
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Entrez Gene | 23512 |
Alt Symbol | CHET9, JJAZ1 |
Species | Human |
Gene Type | protein-coding |
Description | SUZ12 polycomb repressive complex 2 subunit |
Other Description | chET 9 protein|chromatin precipitated E2F target 9 protein|joined to JAZF1 protein|polycomb protein SUZ12|suppressor of zeste 12 homolog|suppressor of zeste 12 protein homolog |
Swissprots | Q96BD9 Q15022 |
Accessions | EAW80258 Q15022 AK074333 AK290014 BAF82703 BC015704 AAH15704 BC018583 D63881 BAA09931 DB501687 ES313164 XM_005257954 XP_005258011 XM_006721794 XP_006721857 XM_011524576 XP_011522878 XM_011524577 XP_011522879 XM_011524578 XP_011522880 NM_015355 NP_056170 |
Function | Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15231737}. |
Tissue Specificity | Overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15684044}. |
Human SUZ12 full length protein - ab196414 from Abcam
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Human SUZ12 peptide - ab12389 from Abcam
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Human SUZ12 protein fragment - ab112401 from Abcam
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SUZ12 Antibody Blocking Peptide - LS-E14135 from LifeSpan Bioscience
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SUZ12 Antibody Blocking Peptide - LS-E11401 from LifeSpan Bioscience
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Recombinant Human SUZ12 Protein - H00023512-Q01 from Novus Biologicals
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SUZ12 Protein Lysate (APL10305) - APL10305 from Aviva Systems Biology
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SUZ12 Protein Lysate (APL10465) - APL10465 from Aviva Systems Biology
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SUZ12 Protein Lysate (APL10466) - APL10466 from Aviva Systems Biology
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SUZ12 Blocking Peptide - 33R-9083 from Fitzgerald
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SUZ12 Blocking Peptide - 33R-2719 from Fitzgerald
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SUZ12 - H00023512-Q01-10 from Acris Antibodies
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SUZ12 - H00023512-Q01-25 from Acris Antibodies
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SUZ12 Peptide - 7701P from ProSci
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Recombinant Human SUZ12 - SUZ12-31487TH from Creative Biomart
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Recombinant Suppressor Of Zeste 12 Homolog (SUZ12) - RPM329Hu01 from Uscn Life Science Inc.
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Recombinant Suppressor Of Zeste 12 Homolog (SUZ12) - RPM329Hu01 from Cloud-clone
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Recombinant Human Polycomb protein SUZ12(SUZ12) - CSB-YP621859HU CSB-EP621859HU CSB-BP621859HU CSB-MP621859HU from Cusabio
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SUZ12 Protein - abx164076 from Abbexa
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SUZ12 - TP302362 from Acris Antibodies
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Polycomb protein SUZ12 (SUZ12), Recombinant Protein - MBS1437089 from MyBioSource
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SUZ12 Recombinant Protein Antigen - NBP2-33834PEP from Novus Biologicals
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SUZ12 Antibody - SH-A16100 from Novatein Biosciences
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Suz12 antibody ( mAb ) , 100 ug - HM-AB2036 from Novatein Biosciences
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Suz12 antibody ( mAb ) , 10 ug - HM-AB2037 from Novatein Biosciences
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