Gene Symbol | SUZ12 |
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Entrez Gene | 23512 |
Alt Symbol | CHET9, JJAZ1 |
Species | Human |
Gene Type | protein-coding |
Description | SUZ12 polycomb repressive complex 2 subunit |
Other Description | chET 9 protein|chromatin precipitated E2F target 9 protein|joined to JAZF1 protein|polycomb protein SUZ12|suppressor of zeste 12 homolog|suppressor of zeste 12 protein homolog |
Swissprots | Q96BD9 Q15022 |
Accessions | EAW80258 Q15022 AK074333 AK290014 BAF82703 BC015704 AAH15704 BC018583 D63881 BAA09931 DB501687 ES313164 XM_005257954 XP_005258011 XM_006721794 XP_006721857 XM_011524576 XP_011522878 XM_011524577 XP_011522879 XM_011524578 XP_011522880 NM_015355 NP_056170 |
Function | Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16618801, ECO:0000269|PubMed:17344414, ECO:0000269|PubMed:18285464}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15231737}. |
Tissue Specificity | Overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15684044}. |
SUZ12 CRISPR/Cas9 KO Plasmid (h) - sc-401551 from Santa Cruz Biotechnology
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SUZ12 HDR Plasmid (h) - sc-401551-HDR from Santa Cruz Biotechnology
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SUZ12 Double Nickase Plasmid (h) - sc-401551-NIC from Santa Cruz Biotechnology
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SUZ12 Double Nickase Plasmid (h2) - sc-401551-NIC-2 from Santa Cruz Biotechnology
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SUZ12 CRISPR Activation Plasmid (h) - sc-401551-ACT from Santa Cruz Biotechnology
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SUZ12 CRISPR Activation Plasmid (h2) - sc-401551-ACT-2 from Santa Cruz Biotechnology
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SUZ12 Lentiviral Activation Particles (h) - sc-401551-LAC from Santa Cruz Biotechnology
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SUZ12 Lentiviral Activation Particles (h2) - sc-401551-LAC-2 from Santa Cruz Biotechnology
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SUZ12 siRNA (h) - sc-45597 from Santa Cruz Biotechnology
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SUZ12 shRNA Plasmid (h) - sc-45597-SH from Santa Cruz Biotechnology
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SUZ12 shRNA (h) Lentiviral Particles - sc-45597-V from Santa Cruz Biotechnology
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SUZ12 RNAi - H00023512-R01 from Novus Biologicals
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MISSION® esiRNA - EHU043331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2407 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2407 from Sigma-Aldrich
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SUZ12 siRNA (Human) - CRH8318 from Cohesion Biosciences
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SUZ12 - MBS8202403 from MyBioSource
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shRNA set against Human Suz12 (NM_015355.2) - SHH421232 from Creative biogene
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Human SUZ12 siRNA - orb268820 from Biorbyt
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SUZ12 shRNA Plasmid (Human) - CHH8318 from Cohesion Biosciences
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SUZ12 miRNA 3'UTR clone - MiUTR4H-TG08687 from Creative biogene
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