| Gene Symbol |
HS2ST1
|
| Entrez Gene |
9653
|
| Alt Symbol |
dJ604K5.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
heparan sulfate 2-O-sulfotransferase 1
|
| Other Description |
2-O-sulfotransferase|2OST
|
| Swissprots |
Q9H441 Q9NUJ9 O75036 Q8TAC5 Q32NB5 Q7LGA3 D3DT22
|
| Accessions |
EAW73170 EAW73171 EAW73172 EAW73173 Q7LGA3 AB007917 BAA32293 AB024568 BAA89250 AF086247 AK023260 BAG51177 BC025384 AAH25384 BC025990 AAH25990 BC108735 AAI08736 BF431947 JF432623 ADZ15840 NM_001134492 NP_001127964 NM_012262 NP_036394
|
| Function |
Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
![Western Blot: Heparan sulfate 2-O-sulfotransferase 1 Overexpression Lysate (Adult Normal) [NBL1-11712] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Heparan sulfate 2-O-sulfotransferase 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7790_Heparan%2520sulfate%25202-O-sulfotransferase%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11712-img0002.jpg)