Gene Symbol | HS2ST1 |
---|---|
Entrez Gene | 9653 |
Alt Symbol | dJ604K5.2 |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate 2-O-sulfotransferase 1 |
Other Description | 2-O-sulfotransferase|2OST |
Swissprots | Q9H441 Q9NUJ9 O75036 Q8TAC5 Q32NB5 Q7LGA3 D3DT22 |
Accessions | EAW73170 EAW73171 EAW73172 EAW73173 Q7LGA3 AB007917 BAA32293 AB024568 BAA89250 AF086247 AK023260 BAG51177 BC025384 AAH25384 BC025990 AAH25990 BC108735 AAI08736 BF431947 JF432623 ADZ15840 NM_001134492 NP_001127964 NM_012262 NP_036394 |
Function | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
HS2ST1 CRISPR/Cas9 KO Plasmid (h) - sc-405010 from Santa Cruz Biotechnology
|
||||||||
HS2ST1 HDR Plasmid (h) - sc-405010-HDR from Santa Cruz Biotechnology
|
||||||||
HS2ST1 Double Nickase Plasmid (h) - sc-405010-NIC from Santa Cruz Biotechnology
|
||||||||
HS2ST1 Double Nickase Plasmid (h2) - sc-405010-NIC-2 from Santa Cruz Biotechnology
|
||||||||
HS2ST1 CRISPR Activation Plasmid (h) - sc-405010-ACT from Santa Cruz Biotechnology
|
||||||||
HS2ST1 CRISPR Activation Plasmid (h2) - sc-405010-ACT-2 from Santa Cruz Biotechnology
|
||||||||
HS2ST1 Lentiviral Activation Particles (h) - sc-405010-LAC from Santa Cruz Biotechnology
|
||||||||
HS2ST1 Lentiviral Activation Particles (h2) - sc-405010-LAC-2 from Santa Cruz Biotechnology
|
||||||||
HS2ST1 siRNA (h) - sc-88331 from Santa Cruz Biotechnology
|
||||||||
HS2ST1 shRNA Plasmid (h) - sc-88331-SH from Santa Cruz Biotechnology
|
||||||||
HS2ST1 shRNA (h) Lentiviral Particles - sc-88331-V from Santa Cruz Biotechnology
|
||||||||
Heparan Sulfate 2-O-Sulfotransferase 1/HS2ST1 RNAi - H00009653-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU095791 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10305 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10305 from Sigma-Aldrich
|
||||||||
HS2ST1 siRNA (Human) - CRH6430 from Cohesion Biosciences
|
||||||||
HS2ST1 - MBS8221874 from MyBioSource
|
||||||||
shRNA set against Human HS2ST1 (NM_012262.3) - SHH314945 from Creative biogene
|
||||||||
Human HS2ST1 siRNA - orb266932 from Biorbyt
|
||||||||
HS2ST1 shRNA Plasmid (Human) - CHH6430 from Cohesion Biosciences
|
||||||||
HS2ST1 miRNA 3'UTR clone - MiUTR3H-07137 from Creative biogene
|