Gene Symbol | HS2ST1 |
---|---|
Entrez Gene | 9653 |
Alt Symbol | dJ604K5.2 |
Species | Human |
Gene Type | protein-coding |
Description | heparan sulfate 2-O-sulfotransferase 1 |
Other Description | 2-O-sulfotransferase|2OST |
Swissprots | Q9H441 Q9NUJ9 O75036 Q8TAC5 Q32NB5 Q7LGA3 D3DT22 |
Accessions | EAW73170 EAW73171 EAW73172 EAW73173 Q7LGA3 AB007917 BAA32293 AB024568 BAA89250 AF086247 AK023260 BAG51177 BC025384 AAH25384 BC025990 AAH25990 BC108735 AAI08736 BF431947 JF432623 ADZ15840 NM_001134492 NP_001127964 NM_012262 NP_036394 |
Function | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |