| Gene Symbol |
P4HTM
|
| Entrez Gene |
54681
|
| Alt Symbol |
EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
|
| Other Description |
HIF-PH4|HIF-prolyl hydroxylase 4|HPH-4|P4H with transmembrane domain|Prolyl hydroxlase domain-containing 4|hypoxia inducible factor prolyl 4 hydroxylase|hypoxia-inducible factor prolyl 4-hydroxylase|hypoxia-inducible factor prolyl hydroxylase 4|proline 4-hydroxylase|transmembrane prolyl 4-hydroxylase
|
| Swissprots |
Q8WV55 Q9NXG6 Q96F22 Q9BW77 Q8TCJ9 Q6PAG6
|
| Accessions |
EAW64934 EAW64935 EAW64936 EAW64937 EAW64938 EAW64939 EAW64940 Q9NXG6 AI079878 AK000269 BAA91045 AK309082 AL713728 CAD28518 AW072069 AY198406 AAO43431 BC000580 AAH00580 BC011710 AAH11710 BC018731 BC047566 AAH47566 BC060321 AAH60321 XM_011533845 XP_011532147 XM_011533846 XP_011532148 XR_940459 NM_177938 NP_808807 NM_177939 NP_808808 NM_017732
|
| Function |
Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.
|
| Tissue Specificity |
Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.
|