P4HTM

Gene Symbol	P4HTM
Entrez Gene	54681
Alt Symbol	EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4
Species	Human
Gene Type	protein-coding
Description	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Other Description	HIF-PH4|HIF-prolyl hydroxylase 4|HPH-4|P4H with transmembrane domain|Prolyl hydroxlase domain-containing 4|hypoxia inducible factor prolyl 4 hydroxylase|hypoxia-inducible factor prolyl 4-hydroxylase|hypoxia-inducible factor prolyl hydroxylase 4|proline 4-hydroxylase|transmembrane prolyl 4-hydroxylase
Swissprots	Q8WV55 Q9NXG6 Q96F22 Q9BW77 Q8TCJ9 Q6PAG6
Accessions	EAW64934 EAW64935 EAW64936 EAW64937 EAW64938 EAW64939 EAW64940 Q9NXG6 AI079878 AK000269 BAA91045 AK309082 AL713728 CAD28518 AW072069 AY198406 AAO43431 BC000580 AAH00580 BC011710 AAH11710 BC018731 BC047566 AAH47566 BC060321 AAH60321 XM_011533845 XP_011532147 XM_011533846 XP_011532148 XR_940459 NM_177938 NP_808807 NM_177939 NP_808808 NM_017732
Function	Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.
Tissue Specificity	Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

P4H-TM (E-18) - sc-100089 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

P4H-TM (N-12) - sc-100090 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

P4H-TM (Y-16) - sc-100091 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-HIF Prolyl Hydroxylases antibody - ab154375 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-HIF Prolyl Hydroxylases antibody - ab40931 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-HIF Prolyl Hydroxylases antibody [EPR3664(2)] - ab109734 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3664(2)

Anti-PHD4/prolyl hydroxylase antibody - ab126943 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-PHD4/prolyl hydroxylase antibody - ab169483 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus) - LS-C49068 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus, Biotin) - LS-C142781 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus, DY650) - LS-C142782 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus, DY488) - LS-C142783 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (aa215-264) - LS-C112120 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus, HRP) - LS-C142784 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus, DY550) - LS-C142785 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (aa323-372) - LS-C107605 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody - LS-C341943 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (C-Terminus) - LS-C287226 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PH4 / P4HTM Antibody (Internal, clone EPR3664(2)) - LS-C138084 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3664(2)

Anti-PH4 / P4HTM Antibody - LS-C335640 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PHD4/HIF Prolyl Hydroxylase 4 Antibody - NB100-295 from Novus Biologicals Prices $99.00, $299.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

PHD4/HIF Prolyl Hydroxylase 4 Antibody - NBP1-83989 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

PHD4/HIF Prolyl Hydroxylase 4 Antibody - 46020002 from Novus Biologicals Prices $429.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PHD4/HIF Prolyl Hydroxylase 4 Antibody - H00054681-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

PHD4/HIF Prolyl Hydroxylase 4 Antibody - H00054681-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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