P4HTM
| Gene Symbol | P4HTM |
|---|---|
| Entrez Gene | 54681 |
| Alt Symbol | EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| Other Description | HIF-PH4|HIF-prolyl hydroxylase 4|HPH-4|P4H with transmembrane domain|Prolyl hydroxlase domain-containing 4|hypoxia inducible factor prolyl 4 hydroxylase|hypoxia-inducible factor prolyl 4-hydroxylase|hypoxia-inducible factor prolyl hydroxylase 4|proline 4-hydroxylase|transmembrane prolyl 4-hydroxylase |
| Swissprots | Q8WV55 Q9NXG6 Q96F22 Q9BW77 Q8TCJ9 Q6PAG6 |
| Accessions | EAW64934 EAW64935 EAW64936 EAW64937 EAW64938 EAW64939 EAW64940 Q9NXG6 AI079878 AK000269 BAA91045 AK309082 AL713728 CAD28518 AW072069 AY198406 AAO43431 BC000580 AAH00580 BC011710 AAH11710 BC018731 BC047566 AAH47566 BC060321 AAH60321 XM_011533845 XP_011532147 XM_011533846 XP_011532148 XR_940459 NM_177938 NP_808807 NM_177939 NP_808808 NM_017732 |
| Function | Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}. |
| Tissue Specificity | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}. |
PH-4 CRISPR/Cas9 KO Plasmid (h) - sc-409966 from Santa Cruz Biotechnology
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PH-4 HDR Plasmid (h) - sc-409966-HDR from Santa Cruz Biotechnology
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PH-4 Double Nickase Plasmid (h) - sc-409966-NIC from Santa Cruz Biotechnology
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PH-4 Double Nickase Plasmid (h2) - sc-409966-NIC-2 from Santa Cruz Biotechnology
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PH-4 CRISPR Activation Plasmid (h) - sc-409966-ACT from Santa Cruz Biotechnology
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PH-4 CRISPR Activation Plasmid (h2) - sc-409966-ACT-2 from Santa Cruz Biotechnology
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PH-4 Lentiviral Activation Particles (h) - sc-409966-LAC from Santa Cruz Biotechnology
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PH-4 Lentiviral Activation Particles (h2) - sc-409966-LAC-2 from Santa Cruz Biotechnology
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P4H-TM siRNA (h) - sc-78320 from Santa Cruz Biotechnology
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P4H-TM shRNA Plasmid (h) - sc-78320-SH from Santa Cruz Biotechnology
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P4H-TM shRNA (h) Lentiviral Particles - sc-78320-V from Santa Cruz Biotechnology
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PHD4/HIF Prolyl Hydroxylase 4 RNAi - H00054681-R01 from Novus Biologicals
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PHD4/HIF Prolyl Hydroxylase 4 RNAi - H00054681-R02 from Novus Biologicals
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MISSION® esiRNA - EHU091681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16242 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16242 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01827 from Sigma-Aldrich
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P4HTM siRNA (Human) - CRJ0176 from Cohesion Biosciences
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PHD4/HIF Prolyl Hydroxylase 4 RNAi - H00054681-R03 from Novus Biologicals
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shRNA set against Human P4HTM (NM_177938.2) - SHH369688 from Creative biogene
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PH-4 CRISPR/Cas9 KO Plasmid (h2) - sc-409966-KO-2 from Santa Cruz Biotechnology
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PH-4 HDR Plasmid (h2) - sc-409966-HDR-2 from Santa Cruz Biotechnology
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P4HTM shRNA Plasmid (Human) - CHJ0176 from Cohesion Biosciences
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P4HTM miRNA 3'UTR clone - MiUTR1H-07832 from Creative biogene
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P4HTM miRNA 3'UTR clone - MiUTR1H-07833 from Creative biogene
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