P4HTM

Gene Symbol	P4HTM
Entrez Gene	54681
Alt Symbol	EGLN4, HIFPH4, P4H-TM, PH-4, PH4, PHD4
Species	Human
Gene Type	protein-coding
Description	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Other Description	HIF-PH4|HIF-prolyl hydroxylase 4|HPH-4|P4H with transmembrane domain|Prolyl hydroxlase domain-containing 4|hypoxia inducible factor prolyl 4 hydroxylase|hypoxia-inducible factor prolyl 4-hydroxylase|hypoxia-inducible factor prolyl hydroxylase 4|proline 4-hydroxylase|transmembrane prolyl 4-hydroxylase
Swissprots	Q8WV55 Q9NXG6 Q96F22 Q9BW77 Q8TCJ9 Q6PAG6
Accessions	EAW64934 EAW64935 EAW64936 EAW64937 EAW64938 EAW64939 EAW64940 Q9NXG6 AI079878 AK000269 BAA91045 AK309082 AL713728 CAD28518 AW072069 AY198406 AAO43431 BC000580 AAH00580 BC011710 AAH11710 BC018731 BC047566 AAH47566 BC060321 AAH60321 XM_011533845 XP_011532147 XM_011533846 XP_011532148 XR_940459 NM_177938 NP_808807 NM_177939 NP_808808 NM_017732
Function	Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. {ECO:0000269|PubMed:17726031}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.
Tissue Specificity	Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:17726031}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PH-4 293T Cell Transient Overexpression Lysate(Denatured) - H00054681-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

P4HTM overexpression lysate - LY403592 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

P4HTM 293 Cell Lysate - 403102 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

PHD4/HIF Prolyl Hydroxylase 4 Overexpression Lysate (Denatured) - H00054681-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PHD4/HIF Prolyl Hydroxylase 4 Overexpression Lysate (Native) - NBL1-14344 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

P4HTM Over-expression Lysate Product - GWB-E5ACD3 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Panoply™ Human P4HTM Knockdown Stable Cell Line - CSC-DC011218 from Creative biogene Category Cell Line Species Human

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