PRG2

Gene Symbol PRG2
Entrez Gene 5553
Alt Symbol BMPG, MBP, MBP1
Species Human
Gene Type protein-coding
Description proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Other Description bone marrow proteoglycan|bone-marrow proteoglycan|eosinophil granule major basic protein|eosinophil major basic protein|natural killer cell activator|proteoglycan 2 preproprotein
Swissprots Q6ICT2 P13727 P81448 A6XMW0 Q14227 B2R5I1
Accessions AAA35796 CBH19418 P13727 AK312195 BAG35128 AU135652 BC005929 AAH05929 BQ445845 BX395670 BX397850 BX454677 CB997424 CR450311 CAG29307 DA841825 DQ846874 ABI63361 DQ893180 ABM84106 DQ896482 ABM87481 M35670 AAA35965 M36805 AAA36203 X14088 CAA32250 X65787 CAA46670 Y00809 CAA68751 Z26248 CAA81207 NM_001243245 NP_001230174 NM_001302926 NP_001289855 NM_001302927 NP_001289856 NM_002728 NP_002719
Function Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.
Subcellular Location Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Tissue Specificity High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7526035}.
Top Pathways Asthma

EMBP (F-2) - sc-365702 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMBP (F-2): sc-365702. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of Decidual and Trophoblastic cells.

EMBP (F-6) - sc-365701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EMBP (F-6): sc-365701. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of Decidual and Trophoblastic cells.

EMBP (A-19) - sc-34012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EMBP (A-19): sc-34012. Western blot analysis of EMBP expression in MEG-01 (A) and RAW 246.7 (B) whole cell lysates.

EMBP (BMK13) - sc-59164 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

EMBP (S-16) - sc-33938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EMBP (S-16): sc-33938. Western blot analysis of mouse recombinant EMBP fusion protein.

EMBP (FL-222) - sc-33556 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EMBP (FL-222): sc-33556. Western blot analysis of EMBP expression in human placenta tissue extract.

EMBP (1.B.787) - sc-59163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Major Basic Protein antibody - ab187523 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Major Basic Protein antibody (ab187523) at 1/500 dilutionLane 1 : BT474 cell extractLane 2 : MCF7 cell extractLane 3 : HL-60 cell extractLane 4 : Mouse kidney extractLane 5 : Mouse heart extractLane 6 : Mouse spleen extract

Anti-Major Basic Protein antibody - ab172108 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Major Basic Protein antibody (ab172108) at 1 µgLane 1 : Major Basic Protein transfected 293T lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-PRG2 antibody - ab154655 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PRG2 antibody (ab154655) at 1/1000 dilutionLane 1 : Jurkat whole cell lysateLane 2 : K562 whole cell lysateLane 3 : THP-1 whole cell lysateLane 4 : HL-60 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-PRG2 antibody [1.B.787] - ab14462 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1.B.787

Anti-PRG2 antibody [1.B.787] - ab14463 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1.B.787

Anti-PRG2 / Proteoglycan 2 Antibody (clone BMK-13, Azide-free) - LS-C23093 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BMK-13

Anti-PRG2 / Proteoglycan 2 Antibody (clone BMK-13) - LS-C85082 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BMK-13

Anti-PRG2 / Proteoglycan 2 Antibody (clone BMK-13) - LS-C134845 from LifeSpan Bioscience

Prices $245.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone BMK-13

Anti-PRG2 / Proteoglycan 2 Antibody - LS-C152882 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-PRG2 / Proteoglycan 2 Antibody (clone BMK-13) - LS-C188701 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BMK-13

Anti-PRG2 / Proteoglycan 2 Antibody - LS-C292477 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-PRG2 / Proteoglycan 2 Antibody (aa80-219, Biotin) - LS-C298863 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRG2 / Proteoglycan 2 Antibody (aa37-215, Biotin) - LS-C298630 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRG2 / Proteoglycan 2 Antibody (aa105-222, Biotin) - LS-C298862 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRG2 / Proteoglycan 2 Antibody (Biotin) - LS-C300100 from LifeSpan Bioscience

Prices $415.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-PRG2 / Proteoglycan 2 Antibody (aa37-215, FITC) - LS-C302783 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRG2 / Proteoglycan 2 Antibody (aa105-222, FITC) - LS-C305476 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PRG2 / Proteoglycan 2 Antibody (FITC) - LS-C304433 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
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