PRG2

Gene Symbol	PRG2
Entrez Gene	5553
Alt Symbol	BMPG, MBP, MBP1
Species	Human
Gene Type	protein-coding
Description	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Other Description	bone marrow proteoglycan|bone-marrow proteoglycan|eosinophil granule major basic protein|eosinophil major basic protein|natural killer cell activator|proteoglycan 2 preproprotein
Swissprots	Q6ICT2 P13727 P81448 A6XMW0 Q14227 B2R5I1
Accessions	AAA35796 CBH19418 P13727 AK312195 BAG35128 AU135652 BC005929 AAH05929 BQ445845 BX395670 BX397850 BX454677 CB997424 CR450311 CAG29307 DA841825 DQ846874 ABI63361 DQ893180 ABM84106 DQ896482 ABM87481 M35670 AAA35965 M36805 AAA36203 X14088 CAA32250 X65787 CAA46670 Y00809 CAA68751 Z26248 CAA81207 NM_001243245 NP_001230174 NM_001302926 NP_001289855 NM_001302927 NP_001289856 NM_002728 NP_002719
Function	Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.
Subcellular Location	Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Tissue Specificity	High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7526035}.
Top Pathways	Asthma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PRG2 protein fragment - ab159183 from Abcam Category Protein Source Wheat germ Species Human

Human PRG2 protein - orb246773 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human Major Basic Protein Protein - abx067909 from Abbexa Category Protein Source E.coli Species Human

Proteoglycan 2 - H00005553-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Major Basic Protein (MBP), Human - 20-7886 from ARP American Research Products Category Protein Prices $511.00 Sizes 50 µg Source E.coli Species Human

PRG2 fusion protein - ag1150 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PRG2, His-tagged - PRG2-44H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human PRG2, GST-tagged - PRG2-45H from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human PRG2, StrepII-tagged - PRG2-46H from Creative Biomart Category Protein Source Human cell line Species Human

Recombinant Major Basic Protein (MBP) - RPB650Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Major Basic Protein (MBP) - RPB650Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Major Basic Protein (MBP) - RPB650Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Major Basic Protein (MBP) - RPB650Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Major Basic Protein (MBP) - RPB650Po01 from Uscn Life Science Inc. Category Protein Source E.coli Species Pig

Recombinant Human Bone marrow proteoglycan(PRG2) - CSB-EP018670HU CSB-BP018670HU CSB-MP018670HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Bone marrow proteoglycan(PRG2) - CSB-YP018670HU from Cusabio Category Protein Source Yeast Species Human

Human BMPG protein (C-His) - orb311665 from Biorbyt Category Protein Prices $366.00, $629.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

PRG2 Recombinant Protein (OPCA02762) - OPCA02762 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Human PRG2 protein - orb54720 from Biorbyt Category Protein Prices $859.00, $910.00, $1,190.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Human PRG2 protein - orb54725 from Biorbyt Category Protein Prices $859.00, $910.00, $1,190.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Recombinant Human Bone marrow proteoglycan(PRG2),partial - CSB-CF018670HU from Cusabio Category Protein Source in vitro E.coli expression system Species Human

PRG2 Recombinant Protein (OPCD05161) - OPCD05161 from Aviva Systems Biology Category Protein Source E.coli Species Human

Recombinant Homo sapiens Bone marrow proteoglycan - AP72732 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast

Human PRG2 protein - orb392334 from Biorbyt Category Protein Prices $374.00, $901.00, $3,536.00 Sizes 10 μl (Trial size), 50 μl, 500 μl Species Human

Bone marrow proteoglycan, Recombinant Protein - MBS953649 from MyBioSource Category Protein Prices $110.00, $190.00, $285.00, $460.00, $750.00, $855.00, $855.00, $1,075.00, $1,180.00, $1,210.00, $1,210.00, $1,670.00, $1,670.00, $2,400.00 Sizes 10 µg (Yeast), 50 µg (Yeast), 100 µg (Yeast), 200 µg (Yeast), 500 µg (Yeast), 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

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