PRG2

Gene Symbol PRG2
Entrez Gene 5553
Alt Symbol BMPG, MBP, MBP1
Species Human
Gene Type protein-coding
Description proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Other Description bone marrow proteoglycan|bone-marrow proteoglycan|eosinophil granule major basic protein|eosinophil major basic protein|natural killer cell activator|proteoglycan 2 preproprotein
Swissprots Q6ICT2 P13727 P81448 A6XMW0 Q14227 B2R5I1
Accessions AAA35796 CBH19418 P13727 AK312195 BAG35128 AU135652 BC005929 AAH05929 BQ445845 BX395670 BX397850 BX454677 CB997424 CR450311 CAG29307 DA841825 DQ846874 ABI63361 DQ893180 ABM84106 DQ896482 ABM87481 M35670 AAA35965 M36805 AAA36203 X14088 CAA32250 X65787 CAA46670 Y00809 CAA68751 Z26248 CAA81207 NM_001243245 NP_001230174 NM_001302926 NP_001289855 NM_001302927 NP_001289856 NM_002728 NP_002719
Function Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.
Subcellular Location Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
Tissue Specificity High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7526035}.
Top Pathways Asthma

EMBP CRISPR/Cas9 KO Plasmid (h) - sc-417813 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP HDR Plasmid (h) - sc-417813-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP Double Nickase Plasmid (h) - sc-417813-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP Double Nickase Plasmid (h2) - sc-417813-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP CRISPR Activation Plasmid (h) - sc-417813-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP CRISPR Activation Plasmid (h2) - sc-417813-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP Lentiviral Activation Particles (h) - sc-417813-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP Lentiviral Activation Particles (h2) - sc-417813-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EMBP siRNA (h) - sc-44577 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EMBP shRNA Plasmid (h) - sc-44577-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EMBP shRNA (h) Lentiviral Particles - sc-44577-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU045031 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® Human Phosphatase - SIHP0685 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0687 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0686 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17396 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17396 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PRG2 siRNA (Human) - CRH3729 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PRG2 RNAi - H00005553-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PRG2 (NM_002728.4) - SHH382480 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PRG2(NM_002728.4) - SHR138874 from Creative biogene

Category siRNA
Species Reactivities Human

PRG2 shRNA Plasmid (Human) - CHH3729 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PRG2 miRNA 3'UTR clone - MiUTR1H-08248 from Creative biogene

Species Reactivities Human
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