| Gene Symbol |
PRG2
|
| Entrez Gene |
5553
|
| Alt Symbol |
BMPG, MBP, MBP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
|
| Other Description |
bone marrow proteoglycan|bone-marrow proteoglycan|eosinophil granule major basic protein|eosinophil major basic protein|natural killer cell activator|proteoglycan 2 preproprotein
|
| Swissprots |
Q6ICT2 P13727 P81448 A6XMW0 Q14227 B2R5I1
|
| Accessions |
AAA35796 CBH19418 P13727 AK312195 BAG35128 AU135652 BC005929 AAH05929 BQ445845 BX395670 BX397850 BX454677 CB997424 CR450311 CAG29307 DA841825 DQ846874 ABI63361 DQ893180 ABM84106 DQ896482 ABM87481 M35670 AAA35965 M36805 AAA36203 X14088 CAA32250 X65787 CAA46670 Y00809 CAA68751 Z26248 CAA81207 NM_001243245 NP_001230174 NM_001302926 NP_001289855 NM_001302927 NP_001289856 NM_002728 NP_002719
|
| Function |
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}.
|
| Subcellular Location |
Bone marrow proteoglycan: Secreted. Note=The proform is secreted.
|
| Tissue Specificity |
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7526035}.
|
| Top Pathways |
Asthma
|