| Gene Symbol |
TOP2A
|
| Entrez Gene |
7153
|
| Alt Symbol |
TOP2, TP2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
topoisomerase (DNA) II alpha 170kDa
|
| Other Description |
DNA gyrase|DNA topoisomerase (ATP-hydrolyzing)|DNA topoisomerase 2-alpha|DNA topoisomerase II, 170 kD|DNA topoisomerase II, alpha isozyme
|
| Swissprots |
Q9HB24 P11388 Q9UQP9 Q9HB25 Q71UQ5 Q71UN1 Q9HB26 B2RTS1 Q9UP44
|
| Accessions |
AAC16736 AAC23518 AAC77388 ABA01496 CAA09762 EAW60661 EAW60662 EAW60663 P11388 AF285157 AAG13403 AF285158 AAG13404 AF285159 AAG13405 AK024080 BC013429 BC062677 BC140791 AAI40792 DB069825 J04088 AAA61209 L47276 L47277 XM_005257632 XP_005257689 XM_011525165 XP_011523467 NM_001067 NP_001058
|
| Function |
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22013166}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22013166}. Note=Generally located in the nucleoplasm.
|