TOP2A

Gene Symbol TOP2A
Entrez Gene 7153
Alt Symbol TOP2, TP2A
Species Human
Gene Type protein-coding
Description topoisomerase (DNA) II alpha 170kDa
Other Description DNA gyrase|DNA topoisomerase (ATP-hydrolyzing)|DNA topoisomerase 2-alpha|DNA topoisomerase II, 170 kD|DNA topoisomerase II, alpha isozyme
Swissprots Q9HB24 P11388 Q9UQP9 Q9HB25 Q71UQ5 Q71UN1 Q9HB26 B2RTS1 Q9UP44
Accessions AAC16736 AAC23518 AAC77388 ABA01496 CAA09762 EAW60661 EAW60662 EAW60663 P11388 AF285157 AAG13403 AF285158 AAG13404 AF285159 AAG13405 AK024080 BC013429 BC062677 BC140791 AAI40792 DB069825 J04088 AAA61209 L47276 L47277 XM_005257632 XP_005257689 XM_011525165 XP_011523467 NM_001067 NP_001058
Function Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity). {ECO:0000250|UniProtKB:Q01320, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:22323612}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:22013166}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22013166}. Note=Generally located in the nucleoplasm.

Topo IIα CRISPR/Cas9 KO Plasmid (h) - sc-400869 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα HDR Plasmid (h) - sc-400869-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα Double Nickase Plasmid (h) - sc-400869-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα Double Nickase Plasmid (h2) - sc-400869-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα CRISPR Activation Plasmid (h) - sc-400869-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα CRISPR Activation Plasmid (h2) - sc-400869-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα Lentiviral Activation Particles (h) - sc-400869-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα Lentiviral Activation Particles (h2) - sc-400869-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Topo IIα siRNA (h) - sc-36695 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Topo IIα shRNA Plasmid (h) - sc-36695-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Topo IIα shRNA (h) Lentiviral Particles - sc-36695-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU073241 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1317 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1347 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1317 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1347 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07662 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07662

TOP2A siRNA (Human) - CRH4906 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TOP2A RNAi - H00007153-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

TOP2A - MBS8222670 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TOP2A (NM_001067.3) - SHH432860 from Creative biogene

Category siRNA
Species Reactivities Human

TOP2A shRNA Plasmid (Human) - CHH4906 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TOP2A miRNA 3'UTR clone - MiUTR3H-00685 from Creative biogene

Species Reactivities Human
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