BSCL2

Gene Symbol BSCL2
Entrez Gene 26580
Alt Symbol GNG3LG, HMN5, PELD, SPG17
Species Human
Gene Type protein-coding
Description Berardinelli-Seip congenital lipodystrophy 2 (seipin)
Other Description Bernardinelli-Seip congenital lipodystrophy type 2 protein|seipin
Swissprots Q96G97 Q567S1 Q9BSQ0 Q96SV1 G3XAE4
Accessions ACA50720 CAF86927 CAI93437 EAW74070 EAW74071 EAW74072 EAW74073 EAW74074 EAW74075 EAW74076 EAW74077 EAW74078 EAW74080 EAW74081 Q96G97 AF052149 AK027524 BAB55175 AK075317 BAC11543 AK223606 BAD97326 AK225029 AK315423 BC004911 AAH04911 BC009866 BC012140 AAH12140 BC041640 AAH41640 BC093048 AAH93048 BG699373 BM763152 BP370169 CD107822 DB178846 DB296305 DQ575792 DQ584208 DQ893483 ABM84409 EU176769 ABW03570 NM_001122955 NP_001116427 NM_001130702 NP_001124174 NM_032667 NP_116056 NR_037948 NR_037949
Function Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. {ECO:0000250, ECO:0000269|PubMed:19278620, ECO:0000269|PubMed:21533227}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:14981520, ECO:0000269|PubMed:16574104, ECO:0000269|PubMed:18458148}; Multi-pass membrane protein {ECO:0000269|PubMed:14981520, ECO:0000269|PubMed:16574104, ECO:0000269|PubMed:18458148}.
Tissue Specificity Expressed in motor neurons in the spinal cord and cortical neurons in the frontal lobe (at protein level). Highly expressed in brain, testis and adipose tissue. {ECO:0000269|PubMed:11479539, ECO:0000269|PubMed:18458148, ECO:0000269|PubMed:18585921}.

Seipin (L-16) - sc-55987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Seipin (L-16): sc-55987. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans.

Anti-BSCL2 antibody - ab106793 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BSCL2 antibody (ab106793) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Brain (Mouse) Tissue LysateLane 3 : Brain (Rat) Tissue LysateLane 4 : Testis (Mouse) Tissue LysateLane 5 : Testis (Rat) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-BSCL2 antibody - ab107170 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BSCL2 antibody (ab107170) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-BSCL2 antibody - ab181761 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (Internal) - LS-C153549 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa78-107, Biotin) - LS-C252722 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa78-107, AP) - LS-C252721 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa78-107, APC) - LS-C252723 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa78-107, Azide-free, HRP) - LS-C252725 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa78-107, FITC) - LS-C252724 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa78-107, PE) - LS-C252726 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa259-358) - LS-C306578 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-BSCL2 Antibody - LS-C309637 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa85-115) - LS-C319890 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BSCL2 Antibody (aa362-410) - LS-C117027 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
BSCL2 antibody LS-C117027 Western blot of U937 cell lysate.

Anti-BSCL2 Antibody (aa78-107) - LS-C156867 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BSCL2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Seipin/BSCL2 Antibody - AF7385 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of IMR‑32 human neuroblastoma cell line and HEK293 human embryonic kidney cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Seipin/BSCL2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7385) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). Specific bands were detected for Seipin/BSCL2 at approximately 70 and 40 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Seipin/BSCL2 Antibody - NBP1-79336 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BSCL2 Antibody [NBP1-79336] - Titration: 0.2-1 ug/ml, Positive Control: U937 cell lysate.

Seipin/BSCL2 Antibody - NBP1-81812 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Seipin/BSCL2 Antibody - H00026580-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Seipin/BSCL2 Antibody [H00026580-D01P] - analysis of BSCL2 expression in transfected 293T cell line by BSCL2 MaxPab rabbit polyclonal antibody. Lane 1: BSCL2 transfected lysate (44.50 KDa). Lane 2: Non-transfected lysate.

Seipin/BSCL2 Antibody (1G4) - H00026580-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G4
Sandwich ELISA: Seipin/BSCL2 Antibody (1G4) [H00026580-M01] - Detection limit for recombinant GST tagged BSCL2 is approximately 0.1ng/ml as a capture antibody.

Seipin/BSCL2 Antibody - H00026580-A02 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Rabbit Anti-BSCL2 Polyclonal Antibody - bs-6311R from Bioss

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Anti-BSCL2 Polyclonal Antibody, Unconjugated (bs-6311R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-BSCL2 antibody produced in rabbit - HPA042394 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BSCL2: <B>Cat. No. HPA042394</B>: Immunohistochemical staining of human cerebral cortex shows moderate cytoplasmic positivity in neuronal cells.

BSCL2 antibody - C-terminal region (ARP50102_P050) - ARP50102_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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