| Gene Symbol |
CCL18
|
| Entrez Gene |
6362
|
| Alt Symbol |
AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
|
| Other Description |
C-C motif chemokine 18|CC chemokine PARC|CC chemokine ligand 18|alternative macrophage activation-associated CC chemokine 1|chemokine (C-C), dendritic|dendritic cell chemokine 1|macrophage inflammatory protein 4|pulmonary and activation-regulated chemokine|small inducible cytokine A18|small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated|small-inducible cytokine A18
|
| Swissprots |
Q53X71 P55774 B5BUM2
|
| Accessions |
AAC32287 AAD30390 BAA34368 CAJ15096 EAW80102 P55774 AB000221 BAA21670 AB451458 BAG70272 BC069700 AAH69700 BC096124 AAH96124 BC096125 AAH96125 BC096126 AAH96126 BC096127 AAH96127 BU617136 CR407660 CAG28588 HQ448456 ADQ32936 Y13710 CAA74039 NM_002988 NP_002979
|
| Function |
Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. {ECO:0000269|PubMed:11745396, ECO:0000269|PubMed:11978786}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. {ECO:0000269|PubMed:11745396}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Chemokine signaling pathway
|