CCL18
| Gene Symbol | CCL18 |
|---|---|
| Entrez Gene | 6362 |
| Alt Symbol | AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) |
| Other Description | C-C motif chemokine 18|CC chemokine PARC|CC chemokine ligand 18|alternative macrophage activation-associated CC chemokine 1|chemokine (C-C), dendritic|dendritic cell chemokine 1|macrophage inflammatory protein 4|pulmonary and activation-regulated chemokine|small inducible cytokine A18|small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated|small-inducible cytokine A18 |
| Swissprots | Q53X71 P55774 B5BUM2 |
| Accessions | AAC32287 AAD30390 BAA34368 CAJ15096 EAW80102 P55774 AB000221 BAA21670 AB451458 BAG70272 BC069700 AAH69700 BC096124 AAH96124 BC096125 AAH96125 BC096126 AAH96126 BC096127 AAH96127 BU617136 CR407660 CAG28588 HQ448456 ADQ32936 Y13710 CAA74039 NM_002988 NP_002979 |
| Function | Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. {ECO:0000269|PubMed:11745396, ECO:0000269|PubMed:11978786}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. {ECO:0000269|PubMed:11745396}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway |
MIP-4 CRISPR/Cas9 KO Plasmid (h) - sc-418009 from Santa Cruz Biotechnology
|
||||||||
MIP-4 HDR Plasmid (h) - sc-418009-HDR from Santa Cruz Biotechnology
|
||||||||
MIP-4 Double Nickase Plasmid (h) - sc-418009-NIC from Santa Cruz Biotechnology
|
||||||||
MIP-4 Double Nickase Plasmid (h2) - sc-418009-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MIP-4 CRISPR Activation Plasmid (h) - sc-418009-ACT from Santa Cruz Biotechnology
|
||||||||
MIP-4 CRISPR Activation Plasmid (h2) - sc-418009-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MIP-4 Lentiviral Activation Particles (h) - sc-418009-LAC from Santa Cruz Biotechnology
|
||||||||
MIP-4 Lentiviral Activation Particles (h2) - sc-418009-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MIP-4 siRNA (h) - sc-60003 from Santa Cruz Biotechnology
|
||||||||
MIP-4 shRNA Plasmid (h) - sc-60003-SH from Santa Cruz Biotechnology
|
||||||||
MIP-4 shRNA (h) Lentiviral Particles - sc-60003-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU129601 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN5603 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5603 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03669 from Sigma-Aldrich
|
||||||||
CCL18 siRNA (Human) - CRH4295 from Cohesion Biosciences
|
||||||||
CCL18/PARC RNAi - H00006362-R01 from Novus Biologicals
|
||||||||
CCL18 - MBS8202838 from MyBioSource
|
||||||||
shRNA set against Human CCL18 (NM_002988.2) - SHH257533 from Creative biogene
|
||||||||
Human CCL18 siRNA - orb264797 from Biorbyt
|
||||||||
CCL18 shRNA Plasmid (Human) - CHH4295 from Cohesion Biosciences
|
||||||||
CCL18 miRNA 3'UTR clone - MiUTR1H-01794 from Creative biogene
|