| Gene Symbol |
SLC30A8
|
| Entrez Gene |
169026
|
| Alt Symbol |
ZNT8, ZnT-8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 30 (zinc transporter), member 8
|
| Other Description |
zinc transporter 8|zinc transporter ZnT-8
|
| Swissprots |
Q8TCL3 A5YM39 A0AVP9 B4DPE0 Q8IWU4
|
| Accessions |
CAD58283 CBX55804 EAW91968 Q8IWU4 AK298294 BAG60552 AL713790 CAD28545 AM392521 CAL37399 AM393307 CAL38185 AY117411 AAM80562 BC015845 BC126446 BC143953 BQ631692 BU949895 EF560713 ABQ59023 XM_011516881 XP_011515183 XM_011516882 XP_011515184 NM_001172811 NP_001166282 NM_001172813 NP_001166284 NM_001172814 NP_001166285 NM_001172815 NP_001166286 NM_173851 NP_776250
|
| Function |
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO:0000269|PubMed:16984975}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}.
|
| Tissue Specificity |
In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16158222, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:17118530, ECO:0000269|PubMed:17971500}.
|
![Western Blot: SLC30A8/ZNT8 Overexpression Lysate (Adult Normal) [NBP2-05081] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC30A8/ZNT8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1039_SLC30A8-ZNT8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05081-img0001.jpg)