Gene Symbol | SLC30A8 |
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Entrez Gene | 169026 |
Alt Symbol | ZNT8, ZnT-8 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 30 (zinc transporter), member 8 |
Other Description | zinc transporter 8|zinc transporter ZnT-8 |
Swissprots | Q8TCL3 A5YM39 A0AVP9 B4DPE0 Q8IWU4 |
Accessions | CAD58283 CBX55804 EAW91968 Q8IWU4 AK298294 BAG60552 AL713790 CAD28545 AM392521 CAL37399 AM393307 CAL38185 AY117411 AAM80562 BC015845 BC126446 BC143953 BQ631692 BU949895 EF560713 ABQ59023 XM_011516881 XP_011515183 XM_011516882 XP_011515184 NM_001172811 NP_001166282 NM_001172813 NP_001166284 NM_001172814 NP_001166285 NM_001172815 NP_001166286 NM_173851 NP_776250 |
Function | Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO:0000269|PubMed:16984975}. |
Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}. |
Tissue Specificity | In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16158222, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:17118530, ECO:0000269|PubMed:17971500}. |
Human SLC30A8 gene - orb92737 from Biorbyt
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SLC30A8 - MBS1272019 from MyBioSource
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Human SLC30A8 cDNA clone(NM_173851.2) - CDFG011017 from Creative Biomart
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Human SLC30A8 cDNA clone(NM_001172813.1) - CDFH017855 from Creative Biomart
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Human SLC30A8 cDNA clone(NM_001172811.1) - CDFH017856 from Creative Biomart
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Human SLC30A8 cDNA clone(NM_001172815.1) - CDFH017857 from Creative Biomart
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Human SLC30A8 cDNA clone(NM_001172814.1) - CDFH017858 from Creative Biomart
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Human SLC30A8 ORF clone(NM_173851.2) - CDCL186217 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_001172811.1) - CDCL175958 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_001172811.1) - CDCL175959 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081958 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081959 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081960 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081961 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081962 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081963 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081964 from Creative Biomart
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human SLC30A8 ORF clone - CDCH081965 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_173851.2) - CDCR322365 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_173851.2) - CDCR322366 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_173851.2) - CDCR322367 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_001172811.1) - CDCR356695 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_001172813.1) - CDCR356696 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_001172811.1) - CDCR356697 from Creative Biomart
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Human SLC30A8 ORF Clone(NM_001172813.1) - CDCR356698 from Creative Biomart
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