SLC30A8
| Gene Symbol | SLC30A8 |
|---|---|
| Entrez Gene | 169026 |
| Alt Symbol | ZNT8, ZnT-8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 30 (zinc transporter), member 8 |
| Other Description | zinc transporter 8|zinc transporter ZnT-8 |
| Swissprots | Q8TCL3 A5YM39 A0AVP9 B4DPE0 Q8IWU4 |
| Accessions | CAD58283 CBX55804 EAW91968 Q8IWU4 AK298294 BAG60552 AL713790 CAD28545 AM392521 CAL37399 AM393307 CAL38185 AY117411 AAM80562 BC015845 BC126446 BC143953 BQ631692 BU949895 EF560713 ABQ59023 XM_011516881 XP_011515183 XM_011516882 XP_011515184 NM_001172811 NP_001166282 NM_001172813 NP_001166284 NM_001172814 NP_001166285 NM_001172815 NP_001166286 NM_173851 NP_776250 |
| Function | Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO:0000269|PubMed:16984975}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}. |
| Tissue Specificity | In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16158222, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:17118530, ECO:0000269|PubMed:17971500}. |
ZnT-8 CRISPR/Cas9 KO Plasmid (h) - sc-417424 from Santa Cruz Biotechnology
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ZnT-8 HDR Plasmid (h) - sc-417424-HDR from Santa Cruz Biotechnology
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ZnT-8 Double Nickase Plasmid (h) - sc-417424-NIC from Santa Cruz Biotechnology
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ZnT-8 Double Nickase Plasmid (h2) - sc-417424-NIC-2 from Santa Cruz Biotechnology
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ZnT-8 CRISPR Activation Plasmid (h) - sc-417424-ACT from Santa Cruz Biotechnology
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ZnT-8 CRISPR Activation Plasmid (h2) - sc-417424-ACT-2 from Santa Cruz Biotechnology
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ZnT-8 Lentiviral Activation Particles (h) - sc-417424-LAC from Santa Cruz Biotechnology
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ZnT-8 Lentiviral Activation Particles (h2) - sc-417424-LAC-2 from Santa Cruz Biotechnology
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ZnT-8 siRNA (h) - sc-77630 from Santa Cruz Biotechnology
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ZnT-8 shRNA Plasmid (h) - sc-77630-SH from Santa Cruz Biotechnology
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ZnT-8 shRNA (h) Lentiviral Particles - sc-77630-V from Santa Cruz Biotechnology
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ZnT-8/SLC30A8 RNAi - H00169026-R01 from Novus Biologicals
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MISSION® esiRNA - EHU009901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19563 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19563 from Sigma-Aldrich
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SLC30A8 siRNA (Human) - CRJ6081 from Cohesion Biosciences
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SLC30A8 - MBS8231436 from MyBioSource
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shRNA set against Human SLC30A8 (NM_173851.2) - SHH410448 from Creative biogene
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shRNA set against Human SLC30A8(NM_173851.2) - SHL006262 from Creative biogene
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Human ZNT8 siRNA - orb276582 from Biorbyt
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SLC30A8 shRNA Plasmid (Human) - CHJ6081 from Cohesion Biosciences
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SLC30A8 miRNA 3'UTR clone - MiUTR1H-09528 from Creative biogene
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