SLC30A8
| Gene Symbol | SLC30A8 |
|---|---|
| Entrez Gene | 169026 |
| Alt Symbol | ZNT8, ZnT-8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 30 (zinc transporter), member 8 |
| Other Description | zinc transporter 8|zinc transporter ZnT-8 |
| Swissprots | Q8TCL3 A5YM39 A0AVP9 B4DPE0 Q8IWU4 |
| Accessions | CAD58283 CBX55804 EAW91968 Q8IWU4 AK298294 BAG60552 AL713790 CAD28545 AM392521 CAL37399 AM393307 CAL38185 AY117411 AAM80562 BC015845 BC126446 BC143953 BQ631692 BU949895 EF560713 ABQ59023 XM_011516881 XP_011515183 XM_011516882 XP_011515184 NM_001172811 NP_001166282 NM_001172813 NP_001166284 NM_001172814 NP_001166285 NM_001172815 NP_001166286 NM_173851 NP_776250 |
| Function | Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO:0000269|PubMed:16984975}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}. |
| Tissue Specificity | In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16158222, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:17118530, ECO:0000269|PubMed:17971500}. |
SLC30A8 / ZNT8 Antibody Blocking Peptide - LS-E30979 from LifeSpan Bioscience
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SLC30A8 / ZNT8 Antibody Blocking Peptide - LS-E17398 from LifeSpan Bioscience
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SLC30A8 Blocking Peptide - 33R-5148 from Fitzgerald
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Human SLC30A8 Protein - abx069135 from Abbexa
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Human SLC30A8 Protein - abx069134 from Abbexa
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Solute Carrier Family 30 Member 8 (SLC30A8), Human - 20-8922 from ARP American Research Products
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Solute Carrier Family 30 Member 8 (SLC30A8), Human - 20-8923 from ARP American Research Products
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Recombinant Human Zinc transporter 8, His-tagged - SLC30A8-03H from Creative Biomart
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Recombinant Human ZNT8 - ZNT8-01H from Creative Biomart
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Recombinant Solute Carrier Family 30 Member 8 (SLC30A8) - RPE490Hu01 from Uscn Life Science Inc.
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Recombinant Solute Carrier Family 30 Member 8 (SLC30A8) - RPE490Hu02 from Uscn Life Science Inc.
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SLC30A8 Peptide - 8485P from ProSci
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SLC30A8 Peptide, Human - M34GP14501H from Creative Peptides
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SLC30A8 Recombinant Protein (OPCD07032) - OPCD07032 from Aviva Systems Biology
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SLC30A8 Recombinant Protein (OPCD07033) - OPCD07033 from Aviva Systems Biology
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Solute Carrier Family 30 Member 8 (SLC30A8), Recombinant Protein - MBS2009993 from MyBioSource
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Solute Carrier Family 30 Member 8 (SLC30A8), Recombinant Protein - MBS2012153 from MyBioSource
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