SLC30A8

Gene Symbol SLC30A8
Entrez Gene 169026
Alt Symbol ZNT8, ZnT-8
Species Human
Gene Type protein-coding
Description solute carrier family 30 (zinc transporter), member 8
Other Description zinc transporter 8|zinc transporter ZnT-8
Swissprots Q8TCL3 A5YM39 A0AVP9 B4DPE0 Q8IWU4
Accessions CAD58283 CBX55804 EAW91968 Q8IWU4 AK298294 BAG60552 AL713790 CAD28545 AM392521 CAL37399 AM393307 CAL38185 AY117411 AAM80562 BC015845 BC126446 BC143953 BQ631692 BU949895 EF560713 ABQ59023 XM_011516881 XP_011515183 XM_011516882 XP_011515184 NM_001172811 NP_001166282 NM_001172813 NP_001166284 NM_001172814 NP_001166285 NM_001172815 NP_001166286 NM_173851 NP_776250
Function Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. {ECO:0000269|PubMed:16984975}.
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}.
Tissue Specificity In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. {ECO:0000269|PubMed:15331542, ECO:0000269|PubMed:16158222, ECO:0000269|PubMed:16984975, ECO:0000269|PubMed:17118530, ECO:0000269|PubMed:17971500}.

ZnT-8 (E-12) - sc-98243 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ZnT-8 (E-12): sc-98243. Western blot analysis of ZnT-8 expression in MIA PaCa-2 (A), HeLa (B), 3T3-L1 (C) and NIH/3T3 (D) whole cell lysates.

Anti-Zinc transporter 8 antibody - ab104690 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Zinc transporter 8 antibody - ab136990 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Zinc transporter 8 antibody (ab136990) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-SLC30A8 / ZNT8 Antibody (aa263-369, Biotin) - LS-C300215 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC30A8 / ZNT8 Antibody (aa263-369, FITC) - LS-C303154 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC30A8 / ZNT8 Antibody (aa1-80, Biotin) - LS-C299908 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC30A8 / ZNT8 Antibody (aa1-80, FITC) - LS-C304788 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC30A8 / ZNT8 Antibody (aa263-369) - LS-C296473 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SLC30A8 / ZNT8.

Anti-SLC30A8 / ZNT8 Antibody (aa107-156) - LS-C111163 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC30A8 antibody LS-C111163 Western blot of NCI-H226 cell lysate.

Anti-SLC30A8 / ZNT8 Antibody (aa1-80) - LS-C296475 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SLC30A8 / ZNT8.

Anti-SLC30A8 / ZNT8 Antibody (aa171-220) - LS-C120485 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from K562 cells, using SLC30A8 Antibody. The lane on the right is treated with the synthesized peptide.

SLC30A8/ZNT8 Antibody - NBP1-68712 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SLC30A8/ZNT8 Antibody [NBP1-68712] - Analysis of extracts from K562 cells, using SLC30A8/ZNT8 Antibody. The lane on the right is treated with the synthesized peptide.

ZnT-8/SLC30A8 Antibody (815039) - MAB7936 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 815039
ZnT‑8 was detected in immersion fixed paraffin-embedded sections of human pancreas using Mouse Anti-Human ZnT‑8 Monoclonal Antibody (Catalog # MAB7936) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counter­stained with hematoxylin (blue). Specific staining was localized to cytoplasm of islet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

ZnT-8/SLC30A8 Antibody - AF7318 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
Immunohistochemistry ZnT-8/SLC30A8 Antibody

ZnT-8/SLC30A8 Antibody - NBP1-59424 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ZNT8 Polyclonal Antibody - bs-15382R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1: Human Raji lysates; Lane 2: Mouse spleen lysates probed with Rabbit Anti-ZNT8 Polyclonal Antibody, Unconjugated (bs-15382R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37˚C.

Anti-SLC30A8 antibody produced in rabbit - SAB4500645 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC30A8: <B>Cat. No. SAB4500645</B>: Immunoblotting analysis of extracts from K562 cells, using Anti-SLC30A8 antibody. The lane on the left was treated with the Anti-SLC30A8 antibody. The lane on the right (negative control) was treated with both Anti-SLC30A8 antibody and the synthesized immunogen peptide.

Anti-SLC30A8 antibody produced in rabbit - SAB2105710 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SLC30A8: <B>Cat. No. SAB2105710</B>: SLC30A8 in NCI-H226 cell lysates with SLC30A8 antibody at 1.0 μg/mL.

SLC30A8 antibody - middle region (ARP48086_P050) - ARP48086_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Human ZnT-8 Antibody - AF7318 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
ZnT-8 in Human Pancreas. ZnT-8 was detected in immersion fixed paraffin-embedded sections of human pancreas using Sheep Anti-Human ZnT-8 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7318) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013 ). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019 ) and counterstained with hematoxylin (blue). Specific staining was localized to islet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections .

Human ZnT-8 Affinity Purified Polyclonal Ab, Sheep IgG - AF7318-SP from R&D Systems

Host Sheep
Clonality Polyclonal
ZnT-8 in Human Pancreas. ZnT-8 was detected in immersion fixed paraffin-embedded sections of human pancreas using Sheep Anti-Human ZnT-8 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7318) at 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to islet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Human ZnT-8 Antibody - MAB7936 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clone 815039
ZnT-8 in Human Pancreas. ZnT-8 was detected in immersion fixed paraffin-embedded sections of human pancreas using Mouse Anti-Human ZnT-8 Monoclonal Antibody (Catalog # MAB7936) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013 ). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002 ) and counter­stained with hematoxylin (blue). Specific staining was localized to cytoplasm of islet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections .

Human ZnT-8 MAb (Clone 815039), Mouse IgG2B - MAB7936-SP from R&D Systems

Host Mouse
Clonality Monoclonal
Clone 815039
ZnT‑8 in Human Pancreas. ZnT‑8 was detected in immersion fixed paraffin-embedded sections of human pancreas using Mouse Anti-Human ZnT‑8 Monoclonal Antibody (Catalog # MAB7936) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counter­stained with hematoxylin (blue). Specific staining was localized to cytoplasm of islet cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

SLC30A8 Antibody (OAAF04476) - OAAF04476 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SLC30A8 Antibody (OAAF07133) - OAAF07133 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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