CUL5

Gene Symbol CUL5
Entrez Gene 8065
Alt Symbol VACM-1, VACM1
Species Human
Gene Type protein-coding
Description cullin 5
Other Description CUL-5|Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)|Vasopressin-activated calcium-mobilizing receptor-1|cullin-5|vasopressin-activated calcium-mobilizing receptor 1
Swissprots A8K960 Q93034 Q9BZC6 O14766
Accessions EAW67101 EAW67102 Q93034 AA099369 AA403092 AA471067 AF017061 AAB70253 AF327710 AAK07472 AK125294 AK292575 BAF85264 BC017838 BC037203 BC063306 AAH63306 H01402 X81882 CAA57465 XM_005271682 XP_005271739 XM_011543012 XP_011541314 XM_011543013 XP_011541315 NM_003478 NP_003469
Function Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Top Pathways Ubiquitin mediated proteolysis

CUL-5 (F-6) - sc-373822 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CUL-5 (F-6): sc-373822. Western blot analysis of CUL-5 expression in HeLa (A), SKBR-3 (B), T-47D (C) and MOLT-4 (D) whole cell lysates.

CUL-5 (I-19) - sc-5325 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CUL-5 (I-19): sc-5325. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

CUL-5 (H-300) - sc-13014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CUL-5 (H-300): sc-13014. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

CUL-5 (N-17) - sc-12371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Cullin 5 antibody - ab186860 from Abcam

Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186860. Blue DAPI for nuclear staining.

Anti-Cullin 5 antibody - ab34840 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Cullin 5 antibody - ab85083 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of formalin-fixed paraffin-embedded human fetal testis tissue section using ab85083 at 1/100 dilution.

Anti-Cullin 5 antibody [EPR14725] - ab184177 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14725
All lanes : Anti-Cullin 5 antibody [EPR14725] (ab184177) at 1/10000 dilutionLane 1 : Hela cell lysateLane 2 : MOLT4 cell lysateLane 3 : T47-D cell lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase conjugated Goat anti-Rabbit IgG (H+L) at 1/1000 dilution

Anti-Cullin 5 antibody - Carboxyterminal end - ab82292 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Cullin 5 antibody - Carboxyterminal end (ab82292) at 1/50 dilution + Hela cell line lysate at 35 µg

Anti-CUL5 / Cullin-5 Antibody (aa4-19) - LS-C90303 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL5 / Cullin-5 Antibody (N-Terminus) - LS-C128433 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL5 / Cullin-5 Antibody (aa526-575) - LS-C31414 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-CUL5 / Cullin-5 Antibody - LS-C341594 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL5 / Cullin-5 Antibody (C-Terminus) - LS-C137066 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CUL5 / Cullin-5 Antibody (aa113-583) IHC-plus™ - LS-B10803 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CUL5 / Cullin-5 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10803 concentration 7.5 ug/ml.

Anti-CUL5 / Cullin-5 Antibody (aa1-50) - LS-C286829 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human Cul5 by Immunohistochemistry. Sample: FFPE section of human non-small cell lung cancer. Antibody: Affinity purified rabbit anti-Cul5 used at a dilution of 1:250.

Anti-CUL5 / Cullin-5 Antibody - LS-C334016 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of U2OS cell using CUL5 antibody. Blue: DAPI for nuclear staining.

Anti-CUL5 / Cullin-5 Antibody (N-Terminus) IHC-plus™ - LS-B361 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CUL5 / Cullin 5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B361 dilution 1:500.

Anti-CUL5 / Cullin-5 Antibody (C-Terminus) - LS-C100206 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CUL5 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CUL5 / Cullin-5 Antibody (aa1-50) - LS-C288928 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Detection of Human Cul5 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Cul5 used at a dilution of1:1000 (1 ug/ml). Detection: DAB.

Cullin 5 Antibody - NBP1-22970 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Cullin 5 Antibody [NBP1-22970] - by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg) and mouse NIH3T3 (M; 50mcg) cells. Antibodies: Affinity purified rabbit anti-Cul5 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 10 mcg/mg lysate. Cul5 was also immunoprecipitated by another rabbit anti-Cul5 antibody, which recognizes a downstream epitope.

Cullin 5 Antibody - NBP1-46462 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Cullin 5 Antibody [NBP1-46462] - Rat spinal cord (paraffin section) using Rabbit antibody to n-terminal of Cullin 5 (Vasopressin activated calcium-mobilizing receptor 1): whole serum at 1 : 200 dilution incubated overnight at 4C, developed with DAB/Ni and counterstaine

Cullin 5 Antibody - NBP1-86868 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Cullin 5 Antibody [NBP1-86868] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

Cullin 5 Antibody - 25160002 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Cullin 5 Antibody - H00008065-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
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